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屋尘和尘螨属提取物中的共同抗原决定簇。

Common antigenic determinants in extracts of house dust and Dermatophagoides species.

作者信息

Dasgupta A, Cunliffe A C

出版信息

Clin Exp Immunol. 1970 Jun;6(6):891-8.

PMID:4097808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712806/
Abstract

Antisera were prepared in rabbits by injection in Freund's adjuvant of extracts from a number of species of mite. Antigenic relationships were examined by geldiffusion precipitation tests. At least one, and probably two antigens were found to be common to the house dust mite, and the related species . These antigens were not detected in mites of the three other genera examined. The presence of common antigens to species would explain the high sensitivity to reported among individuals sensitive to house dust. During the examination of four antisera to house dust made in rabbits, one was found to contain a precipitin to .

摘要

通过将多种螨类提取物与弗氏佐剂混合后注射到兔子体内来制备抗血清。通过凝胶扩散沉淀试验检测抗原关系。发现屋尘螨及相关物种至少有一种、可能有两种共同抗原。在所检测的其他三个属的螨类中未检测到这些抗原。不同物种间存在共同抗原可以解释对屋尘敏感的个体中对屋尘高度敏感的现象。在检测用兔子制备的四种抗屋尘血清时,发现其中一种含有针对[具体物质未明确]的沉淀素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/0773aee8ec20/clinexpimmunol00391-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/a8c23b14e21d/clinexpimmunol00391-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/760533ea071a/clinexpimmunol00391-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/4c8ad2962cbb/clinexpimmunol00391-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/0773aee8ec20/clinexpimmunol00391-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/a8c23b14e21d/clinexpimmunol00391-0102-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/760533ea071a/clinexpimmunol00391-0102-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/4c8ad2962cbb/clinexpimmunol00391-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7f4/1712806/0773aee8ec20/clinexpimmunol00391-0104-b.jpg

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Common antigenic determinants in extracts of house dust and Dermatophagoides species.屋尘和尘螨属提取物中的共同抗原决定簇。
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引用本文的文献

1
Isolation of a potent allergen from house dust mite by interaction with the lectin tridacnin.
Experientia. 1976 May 15;32(5):641-4. doi: 10.1007/BF01990210.

本文引用的文献

1
THE COMPLEXITY OF HOUSE DUST, WITH SPECIAL REFERENCE TO THE PRESENCE OF HUMAN DANDRUFF ALLERGEN.室内灰尘的复杂性,特别提及人头皮屑过敏原的存在。
Int Arch Allergy Appl Immunol. 1965;27:129-44. doi: 10.1159/000229607.
2
Clinical significance of skin reactions to mite extracts in children with asthma.哮喘患儿对螨提取物皮肤反应的临床意义
Br Med J. 1969 Jun 21;2(5659):723-6. doi: 10.1136/bmj.2.5659.723.
3
Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes, 1961) and house dust as a causative antigen in bronchial asthma.
作为支气管哮喘致病抗原的普通屋尘螨(粉尘螨,休斯,1961年)与屋尘之间的变应原一致性。
J Allergy. 1968 Jul;42(1):14-28. doi: 10.1016/0021-8707(68)90128-7.
4
Correspondence: of mites and men.通信:螨虫与人类
J Allergy. 1967 Dec;40(6):355-7. doi: 10.1016/0021-8707(67)90025-1.
5
Mites and house-dust allergy.螨虫与屋尘过敏。
Lancet. 1968 Nov 23;2(7578):1145. doi: 10.1016/s0140-6736(68)91624-3.
6
Mites and house-dust allergy.
Lancet. 1968 Jun 15;1(7555):1270-2. doi: 10.1016/s0140-6736(68)92290-3.
7
Mites and house-dust allergy in bronchial asthma.支气管哮喘中的螨类与屋尘过敏
Lancet. 1968 Jun 15;1(7555):1267-70. doi: 10.1016/s0140-6736(68)92289-7.