Vahlkvist Signe Voss, Lavine Elana, Petersen Thomas Houmann, Rodriguez Mercedes Romano, Aagren Mark, Loftager Anne Sofie L, Bøgelund Mette, da Graca da Maia E Costa Jose Alexandre
Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Denmark.
Department of Paediatrics, Humber River Hospital, Toronto, Ontario, Canada.
J Allergy Clin Immunol Glob. 2025 Jul 1;4(4):100528. doi: 10.1016/j.jacig.2025.100528. eCollection 2025 Nov.
Allergic rhinitis (AR) affects up to 40% of children in the United States and Europe. AR is often associated with asthma and has a negative impact on quality of life for the children and their families.
We investigated the AR burden in children with moderate to severe perennial AR in Canada, Denmark, and the United Kingdom, focusing on the role of concomitant asthma. We assessed the health impact on the children, their receipt of allergy medication and health care services, and the impact on their families.
An online survey was distributed to caregivers of children aged 5 to 17 with moderate to severe perennial AR (both with and without asthma) and to a control group of caregivers of children without allergies.
In total, 877 and 855 caregivers of children with perennial AR and without allergies, respectively, completed the survey. Children with AR and asthma, compared with those without asthma, experienced more sleep disturbances (69% vs 58%), schoolwork limitations (33% vs 22%), daily activities restrictions (55% vs 41%), and missed school hours (7.2 vs 4.6 hours per month). Children with AR and asthma had a higher receipt of allergy medication compared with those without asthma, and they also visited their general practitioner more often (4.6 vs 3.5 times a year). Overall, 32% of all caregivers of children with AR expressed dissatisfaction with allergy medication.
Perennial AR, especially with concomitant asthma, imposes a substantial disease burden in children and their families, highlighting the need for long-term disease control.
在美国和欧洲，高达40%的儿童患有过敏性鼻炎（AR）。AR常与哮喘相关，对儿童及其家庭的生活质量有负面影响。
我们调查了加拿大、丹麦和英国中重度常年性AR患儿的AR负担，重点关注合并哮喘的作用。我们评估了对儿童的健康影响、他们接受过敏药物治疗和医疗服务的情况以及对其家庭的影响。
向5至17岁中重度常年性AR患儿（包括有和没有哮喘的）的照料者以及无过敏儿童的照料者对照组发放了在线调查问卷。
分别有877名和855名常年性AR患儿及无过敏儿童的照料者完成了调查。与无哮喘的儿童相比，患有AR和哮喘的儿童出现更多睡眠障碍（69%对58%）、学业受限（33%对22%）、日常活动受限（55%对41%）以及缺课时间更多（每月7.2小时对4.6小时）。与无哮喘的儿童相比，患有AR和哮喘的儿童接受过敏药物治疗的比例更高，他们看全科医生的频率也更高（每年4.6次对3.5次）。总体而言，所有AR患儿的照料者中有32%对过敏药物治疗表示不满。
常年性AR，尤其是合并哮喘时，给儿童及其家庭带来了沉重的疾病负担，凸显了长期疾病控制的必要性。
