多发性硬化症患者血清和脑脊液中κ和λ免疫球蛋白轻链决定簇的电泳分布
Electrophoretic distribution of kappa and lambda immunoglobulin light chain determinants in serum and cerebrospinal fluid in multiple sclerosis.
作者信息
Zettervall O, Link H
出版信息
Clin Exp Immunol. 1970 Sep;7(3):365-72.
Abstract
The electrophoretic distribution of Kappa and Lambda light chain antigenic determinants were studied in cerebrospinal fluid (CSF) and serum from cases with abnormal Immunoglobulin G patterns on agar gel electrophoresis of CSF. Electrophoretically homogeneous immunoglobulin fractions containing an excess of either Kappa or Lambda determinants were found in CSF but not in serum. The findings indicate the production of monoclonal immunoglobulins within the central nervous system in multiple sclerosis.
摘要
在脑脊液（CSF）免疫球蛋白G琼脂凝胶电泳呈现异常模式的病例的脑脊液和血清中，研究了κ和λ轻链抗原决定簇的电泳分布。在脑脊液中发现了含有过量κ或λ决定簇的电泳均一免疫球蛋白组分，但在血清中未发现。这些发现表明在多发性硬化症中中枢神经系统内产生了单克隆免疫球蛋白。
相似文献
1
2
Qualitative changes in immunoglobulin G in multiple sclerosis-cerebrospinal fluid.多发性硬化症脑脊液中免疫球蛋白G的定性变化
Acta Neurol Scand. 1967;43(S31):180-1. doi: 10.1111/j.1600-0404.1967.tb02109.x.
3
[The gamma globulins of serum and of the cerebrospinal fluid in subacute sclerosing leukoencephalitis and multiple sclerosis].[亚急性硬化性全脑炎和多发性硬化症患者血清及脑脊液中的γ球蛋白]
Acta Neurol Psychiatr Belg. 1967 Oct;67(10):763-70.
4
5
[Demonstration of antigenic determinants bound to the molecular conformation in human immunoglobulins gamma G].[人免疫球蛋白γG中与分子构象结合的抗原决定簇的展示]
Prog Immunobiol Stand. 1970;4:38-43.
6
Gamma globulins of CSF and serum in multiple sclerosis: isoelectric focusing on polyacrylamide gel and agar gel electrophoresis.多发性硬化症中脑脊液和血清的γ球蛋白：聚丙烯酰胺凝胶等电聚焦和琼脂凝胶电泳
Neurology. 1979 Oct;29(10):1381-91. doi: 10.1212/wnl.29.10.1383.
7
Comparison of electrophoresis on agar gel and agarose gel in the evaluation of gamma-globulin abnormalities in cerebrospinal fluid and serum in multiple sclerosis.琼脂凝胶电泳与琼脂糖凝胶电泳在评估多发性硬化症患者脑脊液和血清中γ-球蛋白异常方面的比较。
Clin Chim Acta. 1973 Jul 27;46(4):383-90. doi: 10.1016/0009-8981(73)90251-9.
8
[The behavior of immunoglobulins in multiple sclerosis].[免疫球蛋白在多发性硬化症中的行为]
Acta Neurol (Napoli). 1968 Jul-Aug;23(4):589-99.
9
[Comparative studies on agar gel electrophoresis and cytology of cerebrospinal fluid in multiple sclerosis].[多发性硬化症脑脊液琼脂凝胶电泳与细胞学的比较研究]
Psychiatr Neurol Med Psychol (Leipz). 1973 May;25(5):282-9.
10
The protein fractions in cerebrospinal fluid in the various states of multiple sclerosis.多发性硬化症不同状态下脑脊液中的蛋白质组分。
Eur Neurol. 1970;4(5):267-82. doi: 10.1159/000114028.
引用本文的文献
1
The Blood of the HIV-Infected Patients Contains κ-IgG, λ-IgG, and Bispecific κλ-IgG, Which Possess DNase and Amylolytic Activity.感染HIV患者的血液中含有κ-免疫球蛋白G、λ-免疫球蛋白G和双特异性κλ-免疫球蛋白G，它们具有脱氧核糖核酸酶和淀粉分解活性。
Life (Basel). 2022 Feb 17;12(2):304. doi: 10.3390/life12020304.
2
Detection of oligoclonal IgG kappa and IgG lambda bands in cerebrospinal fluid and serum with Hevylite™ antibodies. comparison with the free light chain oligoclonal pattern.用 Hevylite™ 抗体检测脑脊液和血清中的寡克隆 IgG kappa 和 IgG lambda 带与游离轻链寡克隆模式的比较。
Fluids Barriers CNS. 2012 Feb 23;9(1):5. doi: 10.1186/2045-8118-9-5.
3
Cerebrospinal fluid immunoglobulin quotients, kappa/lambda ratios, and viral antibody titres in neurological disease.神经系统疾病中的脑脊液免疫球蛋白商、κ/λ比值及病毒抗体滴度
J Clin Pathol. 1976 Dec;29(12):1105-15. doi: 10.1136/jcp.29.12.1105.
4
Biochemical findings in multiple sclerosis. III. Immunoglobulins of restricted heterogeneity and light chain distribution in cerebrospinal fluid of patients with multiple sclerosis.
J Neurol. 1976 Apr 23;212(2):151-8. doi: 10.1007/BF00329158.
本文引用的文献
1
Electrophoretic patterns of cerebrospinal fluid and serum compared in normal and pathological conditions.比较正常和病理状态下脑脊液和血清的电泳图谱。
Acta Soc Med Ups. 1952;57(3-4):138-46.
2
CEREBROSPINAL FLUID PARAPROTEINS IN MULTIPLE MYELOMA.多发性骨髓瘤中的脑脊液副蛋白
J Lab Clin Med. 1965 Aug;66:280-93.
3
EFFICIENT LABELLING OF SERUM PROTEINS WITH I-131 USING CHLORAMINE T.使用氯胺T用I-131对血清蛋白进行高效标记
Int J Appl Radiat Isot. 1964 Aug;15:449-56. doi: 10.1016/0020-708x(64)90071-7.
4
ANTIGENIC HETEROGENEITY OF HUMAN RH ANTIBODIES, RHEUMATOID FACTORS, AND COLD AGGLUTININS.人类Rh抗体、类风湿因子和冷凝集素的抗原异质性
Arch Biochem Biophys. 1964 Mar;104:433-7. doi: 10.1016/0003-9861(64)90486-2.
5
LOCALIZATION OF ANTIBODIES IN GROUP I AND GROUP II GAMMA-GLOBULINS.I组和II组γ球蛋白中抗体的定位
J Exp Med. 1963 Nov 1;118(5):817-26. doi: 10.1084/jem.118.5.817.
6
[Studies with gamma globulin labeled with radioiodine on the origin of protein bodies in the cerebrospinal fluid].[关于脑脊液中蛋白质体起源的放射性碘标记丙种球蛋白研究]
Klin Wochenschr. 1958 Sep 15;36(18):857-63. doi: 10.1007/BF01485232.
7
Multiple sclerosis: disturbed kappa: lambda chain ratio of immunoglobulin G in cerebrospinal fluid.多发性硬化症：脑脊液中免疫球蛋白G的κ链与λ链比例失调。
Clin Exp Immunol. 1970 Mar;6(3):435-8.
8
Presence of two types of L polypeptide chains in guinea pig 7S immunoglobulins.豚鼠7S免疫球蛋白中两种L多肽链的存在。
J Exp Med. 1966 Nov 1;124(5):787-803. doi: 10.1084/jem.124.5.787.
9
Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia. A classification of diseases associated with the production of monoclonal-type immunoglobulins.30例非骨髓瘤或巨球蛋白血症的单克隆免疫球蛋白病。与单克隆型免疫球蛋白产生相关的疾病分类。
Am J Med. 1969 Apr;46(4):562-79. doi: 10.1016/0002-9343(69)90075-8.
10
Heterogeneity of heavy (gamma) chain preparations from human gamma G-immunoglobulins.人γG-免疫球蛋白重（γ）链制剂的异质性
Nature. 1966 Jun 11;210(5041):1182-3. doi: 10.1038/2101182b0.
Zotero 插件