Wang Lisha, Chang Tianying, Zhu Tonggang, Hu Wenxin, Wang Xiaodan, Dong Chenxuan, Sun Yu, Zhang Tianpeng, Jiang Yue, Zhao Chunna, Cui Yingzi, Guo Jiajuan, Liao Xing
College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Front Pharmacol. 2025 Sep 4;16:1638147. doi: 10.3389/fphar.2025.1638147. eCollection 2025.
Bertoni ( for short), native to the Amambay Mountains of South America, is a sweet tasting medicinal plant with a long history of use in traditional medical systems. With the increasing global interest in natural products, their ethnopharmacological value and therapeutic potential have received growing attention from researchers, physicians, patients, and consumers. This review aims to comprehensively assess the ethnobotanical traits, traditional uses, pharmacological activities, major constituents, mechanisms of action, and safety profiles of . A comprehensive literature search was conducted using English and Chinese databases-Web of Science, PubMed, Scopus, ScienceDirect, CNKI, Google Scholar, and Elsevier-covering publications up to March 2025, including the keywords "ethnobotany", "geographical distribution", "traditional medicine", "bioactivity", "phytochemistry", "pharmacological activities" and "toxicity". Its taxonomic identity was confirmed using the Medicinal Plant Names Services (MPNS) and Plants of the World Online (POWO). Additional ethnopharmacological monographs and reference works were consulted to supplement database coverage. These findings show that has been traditionally used to lower blood glucose levels, reduce inflammation, and promote digestion. Modern research has identified bioactive metabolites, such as diterpenes, flavonoids, and phenolic acids, which exhibit antioxidant, anti-inflammatory, neuroprotective, and hepatoprotective effects. These properties have therapeutic potential for the management of metabolic disorders, cardiovascular diseases, neurodegenerative conditions and liver dysfunction. Although generally recognized as safe, some studies have reported immunological and reproductive concerns under high-dose or prolonged exposure, underscoring the need for further toxicological and clinical evaluation. In conclusion, this review bridges traditional ethnomedical knowledge with modern pharmacological evidence, providing a foundation for future research and the potential clinical translation of S. rebaudiana in phytotherapy.
贝托尼（简称）原产于南美洲的阿曼拜山脉，是一种味道甜美的药用植物，在传统医学体系中有悠久的使用历史。随着全球对天然产物的兴趣日益增加，它们的民族药理学价值和治疗潜力受到了研究人员、医生、患者和消费者越来越多的关注。本综述旨在全面评估贝托尼的民族植物学特征、传统用途、药理活性、主要成分、作用机制和安全性概况。使用英文和中文数据库——科学网、PubMed、Scopus、ScienceDirect、中国知网、谷歌学术和爱思唯尔——进行了全面的文献检索，涵盖截至2025年3月的出版物，包括关键词“民族植物学”、“地理分布”、“传统医学”、“生物活性”、“植物化学”、“药理活性”和“毒性”。使用药用植物名称服务（MPNS）和世界植物在线（POWO）确认了其分类身份。还查阅了其他民族药理学专著和参考著作以补充数据库覆盖范围。这些发现表明，贝托尼传统上被用于降低血糖水平、减轻炎症和促进消化。现代研究已经鉴定出生物活性代谢物，如二萜类、黄酮类和酚酸类，它们具有抗氧化、抗炎、神经保护和肝保护作用。这些特性对代谢紊乱、心血管疾病、神经退行性疾病和肝功能障碍的管理具有治疗潜力。虽然一般认为是安全的，但一些研究报告了在高剂量或长期接触下的免疫和生殖方面的问题，强调需要进一步进行毒理学和临床评估。总之，本综述将传统民族医学知识与现代药理学证据联系起来，为未来的研究以及贝托尼在植物疗法中的潜在临床转化提供了基础。
