激素抵抗型肾病综合征患儿的健康相关生活质量
Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome.
作者信息
Mahgoob Mohamed, Ali Marwa W E
机构信息
Department of Paediatrics, Minia University, Minia, Egypt.
出版信息
Sultan Qaboos Univ Med J. 2025 May 2;25(1):641-649. doi: 10.18295/2075-0528.2892. eCollection 2025.
OBJECTIVES
Nephrotic syndrome (NS) is considered as a major global health concern, and a higher proportion of children with NS have steroid resistance (SR). This study aimed to assess the health-related quality of life (HRQoL) of children with SRNS.
METHODS
This case-control study was conducted from January to June 2023 at University Children's Hospital, Minia, Egypt. There were 160 participants in total who were divided into 3 groups: 60 participants with SRNS and 2 control groups (one of which had steroid-sensitive NS) that were matched appropriately. Each participant's QoL was assessed using the Pediatric Quality of Life Inventory (PedsQL 4.0 Generic Core Scales).
RESULTS
Children with SRNS had the lowest mean scores across all domains of the PedsQL (<0.001) with duration of the illness and high cumulative glucocorticoids being significant in the prediction of low QoL in those children ( = 0.01 each).
CONCLUSIONS
To properly evaluate and improve the QoL for children with SRNS, coordinated efforts involving paediatric nephrologists and psychiatrists are required.
目的
肾病综合征（NS）被视为全球主要的健康问题，且患有NS的儿童中较高比例存在激素抵抗（SR）。本研究旨在评估激素抵抗型肾病综合征（SRNS）患儿的健康相关生活质量（HRQoL）。
方法
本病例对照研究于2023年1月至6月在埃及米尼亚大学儿童医院进行。共有160名参与者，分为3组：60名SRNS患儿和2个对照组（其中一组为激素敏感型NS），并进行了适当匹配。使用儿童生活质量量表（PedsQL 4.0通用核心量表）评估每位参与者的生活质量。
结果
SRNS患儿在PedsQL所有领域的平均得分最低（<0.001），疾病持续时间和高累积糖皮质激素水平对这些患儿低生活质量的预测具有显著意义（均为 = 0.01）。
结论
为了正确评估和改善SRNS患儿的生活质量，需要儿科肾病学家和精神科医生共同努力。
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