Lataifeh Hanin, Abuhijla Fawzi, Wahbeh Lina, Abuhijlih Ramiz, Asha Wafa, Alzibdeh Abdullah, Jaber Omar, Mohamad Issa, Abdel-Razeq Hikmat
Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan.
Department of Pathology, King Hussein Cancer Center, Amman 11941, Jordan.
Oncol Lett. 2025 Sep 4;30(5):510. doi: 10.3892/ol.2025.15256. eCollection 2025 Nov.
Adenoid cystic carcinoma (AdCC) of the breast is a subtype of triple-negative breast cancer characterized by a distinct indolent behavior, with extremely rare lymphatic involvement and a late onset of distant metastasis occurring several years post-diagnosis. Due to its favorable prognosis, therapeutic guidelines include surgical resection with adjuvant radiotherapy, with no significant benefit of chemotherapy. The present study discusses the case of a 77-year-old female patient who presented with a right-sided breast mass. Biopsy confirmed a grade 2 AdCC transitioning to a higher grade in some areas. The patient underwent a wide local excision and adjuvant radiotherapy was planned; however, during a simulation computed tomography scan performed 6 weeks after surgery, a complex mass at the ipsilateral axillary tail was detected and proved to be disease recurrence on biopsy. Restaging imaging studies showed metastatic involvement of the regional lymph nodes, lungs, liver, bones and brain. The patient received three cycles of palliative chemotherapy, but then clinically deteriorated and passed away 7 months after the initial diagnosis. Notably, the relatively large tumor size (6.4 cm) and the presence of high-grade morphology may have contributed to the poor outcome of the patient. In addition, the current case is one of the unique reported instances in the literature where the interval between treatment and recurrence was <3 months, as well as being one of the few cases that exhibited lymphatic involvement. The present report underscores the importance of further understanding the variable presentations of AdCC.
乳腺腺样囊性癌（AdCC）是三阴性乳腺癌的一种亚型，其特点是具有独特的惰性病程，极少发生淋巴转移，远处转移在诊断数年后才会出现。因其预后良好，治疗指南包括手术切除加辅助放疗，化疗并无显著益处。本研究讨论了一名77岁女性患者的病例，该患者右侧乳房出现肿块。活检证实为2级AdCC，部分区域已转变为高级别。患者接受了广泛局部切除，并计划进行辅助放疗；然而，在术后6周进行的模拟计算机断层扫描中，在同侧腋窝尾部发现了一个复杂肿块，活检证实为疾病复发。重新分期的影像学检查显示区域淋巴结、肺、肝、骨和脑均有转移。患者接受了三个周期的姑息化疗，但随后临床病情恶化，在初次诊断后7个月去世。值得注意的是，相对较大的肿瘤大小（6.4厘米）和高级别形态的存在可能导致了患者的不良预后。此外，本病例是文献中报道的治疗与复发间隔<3个月的罕见病例之一，也是少数出现淋巴转移的病例之一。本报告强调了进一步了解AdCC不同表现的重要性。
