Pánek David, Donchev Toni Slavchev
DP Neuro, s.r.o. Prague Czech Republic.
Medical Center "Intermedica" Sofia Bulgaria.
PCN Rep. 2025 Sep 19;4(3):e70200. doi: 10.1002/pcn5.70200. eCollection 2025 Sep.
Transcranial magnetic stimulation (TMS) is an emerging treatment for binge eating (BE). TMS uses noninvasive magnetic pulses to stimulate the prefrontal cortex, which plays a role in decision-making and self-regulation. Early research suggests that TMS can reduce BE episodes by modulating brain activity linked to cravings and compulsive behavior. This article aims to evaluate the efficacy and safety of a novel TMS device with ExoTMS™ Technology for alleviating BE symptoms.
Subjects underwent six TMS sessions and a 1-month follow-up. The Binge Eating Scale (BES) was administered at baseline, posttreatment, and follow-up to assess symptom severity. Weight was recorded at the same intervals. Therapy comfort was evaluated after the sixth session. The Subject Satisfaction Questionnaire was completed posttreatment and at follow-up. Adverse events and side effects were monitored throughout the study. Data from two identically designed studies were pooled for analysis.
A total of 38 subjects were analyzed. BES scores significantly decreased posttreatment (-37.8%, < 0.001) and at follow-up (-47.9%, < 0.001). At 1 month, 73.7% of subjects achieved BE remission. Average weight loss was -1.3 ± 1.1 kg posttreatment and -1.8 ± 1.3 kg at follow-up. Comfort was rated positively by 92.1% of participants. At follow-up, 89.5% reported reduced cravings and snacking, 86.8% noted improved self-control and well-being, and 94.7% were satisfied with the treatment.
TMS shows promise as a safe and effective intervention for reducing BE symptoms, supported by both objective clinical measures and subjective patient-reported outcomes.
经颅磁刺激（TMS）是一种新兴的暴饮暴食（BE）治疗方法。TMS使用无创磁脉冲刺激前额叶皮层，前额叶皮层在决策和自我调节中起作用。早期研究表明，TMS可通过调节与渴望和强迫行为相关的大脑活动来减少BE发作。本文旨在评估采用ExoTMS™技术的新型TMS设备缓解BE症状的疗效和安全性。
受试者接受6次TMS治疗及1个月的随访。在基线、治疗后和随访时使用暴饮暴食量表（BES）评估症状严重程度。在相同时间间隔记录体重。在第6次治疗后评估治疗舒适度。治疗后和随访时完成受试者满意度问卷。在整个研究过程中监测不良事件和副作用。汇总两项设计相同的研究数据进行分析。
共分析了38名受试者。治疗后BES评分显著降低（-37.8%，P<0.001），随访时降低更明显（-47.9%，P<0.001）。1个月时，73.7%的受试者实现了BE缓解。治疗后平均体重减轻-1.3±1.1kg，随访时为-1.8±1.3kg。92.1%的参与者对治疗舒适度给予了积极评价。随访时，89.5%的人报告渴望和吃零食减少，86.8%的人指出自我控制和幸福感有所改善，94.7%的人对治疗感到满意。
TMS作为一种安全有效的干预措施，在减轻BE症状方面显示出前景，这得到了客观临床指标和患者主观报告结果的支持。
