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他达拉非致慢性左束支传导阻滞患者发生急性肺水肿

Flash Pulmonary Edema Triggered by Tadalafil Use in a Patient With Chronic Left Bundle Branch Block.

作者信息

Roytenberg Renat, Zamudio Herrera Oscar Rodrigo

机构信息

Department of Cardiology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

出版信息

Cureus. 2025 Sep 17;17(9):e92534. doi: 10.7759/cureus.92534. eCollection 2025 Sep.

Abstract

This case report discusses the diagnosis and management of flash pulmonary edema (FPE) in a 61-year-old male patient with a history of uncontrolled hypertension, type 2 diabetes, dyslipidemia, erectile dysfunction, and chronic complete left bundle branch block. The patient presented with acute respiratory distress two hours after tadalafil use. Evaluation revealed hypoxemia and diffuse pulmonary edema, with echocardiography revealing normal systolic function and tissue Doppler imaging suggesting grade I diastolic dysfunction. The patient's symptoms resolved with oxygen, diuresis, and discontinuation of tadalafil. This case emphasizes the need for caution when prescribing phosphodiesterase type 5 inhibitors such as tadalafil to patients with structural or conduction cardiac abnormalities and the importance of prompt recognition and management of FPE in this population.

摘要

本病例报告讨论了一名61岁男性患者的闪发性肺水肿(FPE)的诊断和治疗,该患者有未控制的高血压、2型糖尿病、血脂异常、勃起功能障碍和慢性完全性左束支传导阻滞病史。患者在服用他达拉非两小时后出现急性呼吸窘迫。评估显示低氧血症和弥漫性肺水肿,超声心动图显示收缩功能正常,组织多普勒成像提示I级舒张功能障碍。患者的症状通过吸氧、利尿和停用他达拉非得到缓解。本病例强调,对于有心脏结构或传导异常的患者,在开具他达拉非等5型磷酸二酯酶抑制剂时需谨慎,以及在该人群中及时识别和处理FPE的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b27/12444807/e299ef066a8a/cureus-0017-00000092534-i01.jpg

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