de Oliveira Clarissa Aires, Iorio Eugenio Luigi, Espíndola Foued Salmen
Biochemistry and Molecular Biology Laboratory, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia 38408-100, Brazil.
Program of Post-Graduation in Health Science, Federal University of Uberlandia, Uberlandia 38408-100, Brazil.
Pediatr Rep. 2025 Sep 12;17(5):92. doi: 10.3390/pediatric17050092.
This case report describes a patient (male, 10 years old) with Autism Spectrum Disorder (ASD) and multiple comorbidities, including epilepsy, gastrointestinal and sleep disturbances, and obesity. Whole-exome sequencing (WES) identified two variants of uncertain significance (VUS) in the gene. Mutations in this gene are associated with spinocerebellar ataxia type 18 (SCA18). However, this finding did not correlate with the clinical presentation of the patient. This study evaluates the effects of Radio Electric Asymmetric Conveyer (REAC) stimulation on the cognitive-behavioral dysfunctions of a child with severe ASD and multiple comorbidities. Two stimulation protocols-Neuro Postural Optimization (NPO) and Neuro Psychophysical Optimization (NPPO)-and REAC were performed sequentially. After five weeks of treatment, a 34.9% reduction in total scores on the Autism Treatment Evaluation Checklist (ATEC) and an 8.2% on the Autism Behavior Checklist (ABC) were observed. Assessment of the severity of ASD symptoms using the Childhood Autism Rating Scale (CARS) tool showed less pronounced improvement. The REAC intervention yielded a reduction in Social Relating impairment and an improvement in Sensory/Cognitive Awareness. Further research in this area should employ extended REAC protocols to replicate and amplify clinical responses among individuals with ASD.
本病例报告描述了一名患有自闭症谱系障碍（ASD）及多种合并症的患者（男性，10岁），这些合并症包括癫痫、胃肠道和睡眠障碍以及肥胖。全外显子组测序（WES）在该基因中鉴定出两个意义未明的变异（VUS）。该基因的突变与18型脊髓小脑共济失调（SCA18）相关。然而，这一发现与患者的临床表现并不相关。本研究评估了射频不对称传导器（REAC）刺激对一名患有重度ASD及多种合并症儿童认知行为功能障碍的影响。依次进行了两种刺激方案——神经姿势优化（NPO）和神经心理物理优化（NPPO）以及REAC。治疗五周后，观察到自闭症治疗评估量表（ATEC）总分降低了34.9%，自闭症行为量表（ABC）降低了8.2%。使用儿童自闭症评定量表（CARS）工具评估ASD症状的严重程度显示改善不太明显。REAC干预使社交关系障碍有所减轻，感觉/认知意识有所改善。该领域的进一步研究应采用扩展的REAC方案，以在ASD个体中复制并放大临床反应。
