Singh Bipneet, Kalra Shivam, Khanna Tejasvini, Kohli Isha, Kumar Vikash, Sohal Aalam, Sejpal Divyesh
Henry Ford Jackson, 159, W Michigan Ave, Jackson, MI 49201, USA.
Trident Medical Center, North Charleston, SC 29406, USA.
Epidemiologia (Basel). 2025 Sep 2;6(3):52. doi: 10.3390/epidemiologia6030052.
Patients with inflammatory bowel disease (IBD) are at increased risk of developing other autoimmune disorders due to possible shared genetic, environmental, and immunological mechanisms. While autoimmune diseases are frequently observed in patients with IBD, data quantifying their inpatient prevalence and their association with outcomes such as mortality remain limited. National Inpatient Sample (NIS) 2016-2020 and International Classification of Diseases 10th Version, Clinical Modification (ICD-10-CM) diagnosis codes were used to identify patients with IBD and autoimmune conditions. A multivariate logistic regression analysis to identify an association between various autoimmune diseases and various IBDs was performed. The study population included 141,478,025 patients. An association was found between 24 autoimmune conditions and IBD. Our study identified autoimmune comorbidities that are more prevalent in IBD patients. We found that polymyositis, AIHA, ITP, and thrombotic microangiopathy are associated with a higher risk of in-hospital mortality. Psoriasis and hypothyroidism are associated with a lower risk of in-hospital mortality. Further studies are needed to explore the mechanisms responsible.
由于可能存在共同的遗传、环境和免疫机制，炎症性肠病（IBD）患者发生其他自身免疫性疾病的风险增加。虽然IBD患者中经常观察到自身免疫性疾病，但量化其住院患病率及其与死亡率等结局的关联的数据仍然有限。使用2016 - 2020年国家住院患者样本（NIS）和国际疾病分类第10版临床修订本（ICD - 10 - CM）诊断代码来识别IBD和自身免疫性疾病患者。进行了多变量逻辑回归分析，以确定各种自身免疫性疾病与各种IBD之间的关联。研究人群包括141,478,025名患者。发现24种自身免疫性疾病与IBD之间存在关联。我们的研究确定了在IBD患者中更普遍的自身免疫性合并症。我们发现多发性肌炎、自身免疫性溶血性贫血、免疫性血小板减少症和血栓性微血管病与住院死亡率较高相关。银屑病和甲状腺功能减退与住院死亡率较低相关。需要进一步研究以探索其潜在机制。
