Sheehan Kevin M, Moloney Geraldine, Murphy Olive, Ryan Paul, Hayes Triona, Harney Madeleine R, Harney Michael, O'Connell Oisin
Department of Radiology, University of Galway, H91 V4AY Galway, Ireland.
Department of Infectious Diseases, Galway University Hospital, H91 YR71 Galway, Ireland.
Infect Dis Rep. 2025 Aug 22;17(5):103. doi: 10.3390/idr17050103.
, formerly known as the genus, is a Gram-positive organism known for its characteristic bright yellow colonies. While abundant in nature, it is very rarely linked to pathogenesis in humans. While there is no classical presentation for -associated infections, cases tend to be foreign body-related or involve immunocompromised patients. Rates of -associated infections have been hypothesised to rise in the future, due to rising numbers of immunocompromised patients in the community and increasing usage of foreign bodies such as prostheses and long-term catheters. Existing technical difficulties regarding misidentifying cultures as other species (often other coryneforms) may also play a significant role in the low number of documented cases, and this may change in the near future with diagnostic advancements such as whole genomic sequencing. A 57-year-old immunocompetent Irish male presented with concomitant neck and lung masses. Notably, this was found to be directly following a recent dental procedure. During extensive investigations, was isolated from biopsied lung tissue using 16S ribosomal ribonucleic acid gene-sequencing analysis. The patient was treated with long-term oral amoxicillin and safely discharged, with both masses showing measurable reductions in size on subsequent imaging. Should represent the causative pathological organism in this case, then we believe this to represent a potential novel documented presentation of the organism's pathogenesis in humans. We provide detailed discussion surrounding the successful management of this patient and the evaluation of the evolving differential diagnosis throughout this case.
(该菌)以前被称为(某菌属),是一种革兰氏阳性菌,以其特征性的亮黄色菌落而闻名。虽然在自然界中大量存在,但它与人类发病机制的关联非常罕见。虽然与(该菌)相关的感染没有典型表现,但病例往往与异物相关或涉及免疫功能低下的患者。由于社区中免疫功能低下患者数量的增加以及假体和长期导管等异物使用的增多,有人推测未来与(该菌)相关的感染率将会上升。在将培养物误鉴定为其他物种(通常是其他棒状杆菌)方面存在的现有技术难题,也可能在已记录病例数量较少中起重要作用,而随着全基因组测序等诊断技术的进步,这种情况在不久的将来可能会改变。一名57岁免疫功能正常的爱尔兰男性出现颈部和肺部肿物。值得注意的是,这是在最近一次牙科手术后直接发现的。在广泛的检查过程中,通过16S核糖体核糖核酸基因测序分析从活检的肺组织中分离出了(该菌)。患者接受了长期口服阿莫西林治疗并安全出院,后续影像学检查显示两个肿物大小均有明显缩小。如果(该菌)是此病例中的致病病原体,那么我们认为这代表了该菌在人类发病机制中一种潜在的新的记录表现。我们围绕该患者的成功治疗以及整个病例中不断演变的鉴别诊断评估进行了详细讨论。