泌尿道感染中的分泌型免疫球蛋白A
Secretory IgA in urinary tract infections.
作者信息
Kaufman D B, Katz R, McIntosh R M
出版信息
Br Med J. 1970 Nov 21;4(5733):463-5. doi: 10.1136/bmj.4.5733.463.
Abstract
Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals-3.3 to 0.78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.
摘要
通过放射免疫扩散法测定的分泌型免疫球蛋白A，在患有慢性复发性非梗阻性尿路感染的儿童尿液中与正常儿童尿液中的情况进行了比较。同时还测定了免疫球蛋白A、免疫球蛋白G和免疫球蛋白M。两组均发现免疫球蛋白A水平缺乏和降低；然而，感染组免疫球蛋白A的平均水平显著高于正常组，分别为3.3毫克/24小时和0.78毫克/24小时。发现分泌型免疫球蛋白A是在膀胱局部产生的。提示免疫球蛋白A水平反映了对感染的抗体反应。
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