泌尿道感染中的分泌型免疫球蛋白A
Secretory IgA in urinary tract infections.
作者信息
Kaufman D B, Katz R, McIntosh R M
出版信息
Br Med J. 1970 Nov 21;4(5733):463-5. doi: 10.1136/bmj.4.5733.463.
Abstract
Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals-3.3 to 0.78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.
摘要
通过放射免疫扩散法测定的分泌型免疫球蛋白A，在患有慢性复发性非梗阻性尿路感染的儿童尿液中与正常儿童尿液中的情况进行了比较。同时还测定了免疫球蛋白A、免疫球蛋白G和免疫球蛋白M。两组均发现免疫球蛋白A水平缺乏和降低；然而，感染组免疫球蛋白A的平均水平显著高于正常组，分别为3.3毫克/24小时和0.78毫克/24小时。发现分泌型免疫球蛋白A是在膀胱局部产生的。提示免疫球蛋白A水平反映了对感染的抗体反应。
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本文引用的文献
1
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J Exp Med. 1965 Jan 1;121(1):101-24. doi: 10.1084/jem.121.1.101.
2
THE SELECTIVE OCCURENCE OF GAMMA-1A GLOBULINS IN CERTAIN BODY FLUIDS.γ-1A球蛋白在某些体液中的选择性出现。
J Clin Invest. 1963 Oct;42(10):1552-60. doi: 10.1172/JCI104840.
3
GAMMA-GLOBULINS: QUANTITATIVE RELATIONSHIPS IN HUMAN SERUM AND NONVASCULAR FLUIDS.γ球蛋白：人血清和非血管性体液中的定量关系
Science. 1963 Nov 22;142(3595):1080-1. doi: 10.1126/science.142.3595.1080.
4
The separation and characterization of proteins intrinsic to nasal secretion.鼻分泌物内源性蛋白质的分离与特性分析。
J Immunol. 1966 Sep;97(3):369-78.
5
On the mechanisms of transport and biological significance of antibodies in external secretions.关于外分泌液中抗体的转运机制及生物学意义
Arthritis Rheum. 1969 Feb;12(1):45-50. doi: 10.1002/art.1780120108.
6
Natural antibodies of human serum, saliva, and urine reactive with Escherichia coli.人血清、唾液和尿液中与大肠杆菌反应的天然抗体。
Proc Soc Exp Biol Med. 1968 Jul;128(3):722-7. doi: 10.3181/00379727-128-33109.
7
Localization of 11 S external secretory IgA by immunofluorescence in tissues lining the oral and respiratory passages in man.
J Immunol. 1968 Apr;100(4):706-17.
8
Secretory gamma-A in normal urine.正常尿液中的分泌型γ-球蛋白A
J Clin Invest. 1968 May;47(5):1162-71. doi: 10.1172/JCI105805.
9
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Am J Med. 1968 Feb;44(2):168-78. doi: 10.1016/0002-9343(68)90148-4.
10
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Am J Dis Child. 1968 Feb;115(2):239-46. doi: 10.1001/archpedi.1968.02100010241013.
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