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Characterization of Aeromonas hydrophila isolated from freshwater fish with control trial.

作者信息

Shabana Safaa M, Rashed M A, Atia Ayman A, El-Hady Hala A M Abd

机构信息

Bacteriology Unit, Kafrelsheikh Provincial Lab, Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza, Egypt.

Fish Diseases Unit, Kafrelsheikh Provincial Lab, Animal Health Research Institute, Agricultural Research Center (ARC), Giza, Egypt.

出版信息

Sci Rep. 2025 Sep 23;15(1):32668. doi: 10.1038/s41598-025-19907-6.

DOI:10.1038/s41598-025-19907-6
PMID:40987797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12457639/
Abstract

Aeromonas hydrophila is an opportunistic pathogen that is highly important for freshwater fish. In the present study, two freshwater fish species Nile tilapia (Oreochromis niloticus) and Mullet (Mugil cephalus) collected from various fish farms in Kafrelsheikh Governorate, Egypt. The fish samples were examined to determine Aeromonas hydrophila presence (A. hydrophila). In addition, a treatment trial was conducted involving four groups of Nile tilapia fish, which treated with florfenicol (FFC) and oxytetracycline (OTC) based on the antimicrobial susceptibility test results. According to the findings, 12 (20%) A. hydrophila strains were isolated from a total of 60 collected fish samples (30 of Nile tilapia and Mullet with percentages of 30% and 10%, respectively). Based on species-specific 16 S rRNA genes, six (6) isolates were identified as A. hydrophila and carried aerolysin (aerA) and hemolysin (hylA) virulence genes, with percentages of 83.3% and 50%, respectively. Whereas, the antimicrobial resistance gene results were blaTEM with percent (100%) and aadA1 (83.3%). Histopathological changes were significantly reduced in all assessed organs (liver, spleen, kidney, and gills) in the FFC group compared to the OTC-treated group. The prevalence of virulent and multidrug-resistant A. hydrophila in aquaculture poses significant risks to fish health, economic productivity, and public health.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/0e35c2d4c769/41598_2025_19907_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/045573a47f7c/41598_2025_19907_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/0b4c996ddbb2/41598_2025_19907_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a3998d2ea0ec/41598_2025_19907_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/81fa22f7c9cb/41598_2025_19907_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/f183453436a0/41598_2025_19907_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a4a00c45bf6e/41598_2025_19907_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a313f891def2/41598_2025_19907_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/0e35c2d4c769/41598_2025_19907_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/045573a47f7c/41598_2025_19907_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/0b4c996ddbb2/41598_2025_19907_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a3998d2ea0ec/41598_2025_19907_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/81fa22f7c9cb/41598_2025_19907_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/f183453436a0/41598_2025_19907_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a4a00c45bf6e/41598_2025_19907_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/a313f891def2/41598_2025_19907_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0143/12457639/0e35c2d4c769/41598_2025_19907_Fig8_HTML.jpg

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本文引用的文献

1
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Sci Rep. 2025 Feb 18;15(1):5920. doi: 10.1038/s41598-025-89465-4.
2
Bacterial Quality and Molecular Detection of Food Poisoning Virulence Genes Isolated from Nasser Lake Fish, Aswan, Egypt.从埃及阿斯旺纳赛尔湖鱼类中分离出的食物中毒毒力基因的细菌质量及分子检测
Int J Food Sci. 2024 Jun 13;2024:6095430. doi: 10.1155/2024/6095430. eCollection 2024.
3
Phenotypic, molecular detection, and Antibiotic Resistance Profile (MDR and XDR) of Aeromonas hydrophila isolated from Farmed Tilapia zillii and Mugil cephalus.
从养殖的齐氏罗非鱼和尖嘴鲈中分离的嗜水气单胞菌的表型、分子检测和抗生素耐药谱（MDR 和 XDR）。
BMC Vet Res. 2024 Mar 8;20(1):84. doi: 10.1186/s12917-024-03942-y.
4
Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila.水飞蓟素增强了实验感染嗜水气单胞菌的尼罗罗非鱼对土霉素治疗的反应。
Sci Rep. 2023 Sep 27;13(1):16235. doi: 10.1038/s41598-023-43270-z.
5
Impacts of florfenicol on immunity, antioxidant activity, and histopathology of Oreochromis niloticus: a potential protective effect of dietary spirulina platensis.氟苯尼考对尼罗罗非鱼免疫、抗氧化活性和组织病理学的影响：螺旋藻的潜在保护作用。
Vet Res Commun. 2024 Feb;48(1):125-138. doi: 10.1007/s11259-023-10189-9. Epub 2023 Aug 11.
6
Multidrug-resistant Aeromonas bacteria prevalence in Nile tilapia broodstock.尼罗罗非鱼亲鱼中耐药气单胞菌的流行情况。
BMC Microbiol. 2023 Mar 24;23(1):80. doi: 10.1186/s12866-023-02827-8.
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Emergence of extensively drug-resistant complex isolated from wild (striped mullet) and Mediterranean seawater.从野生（条纹鲻鱼）和地中海海水中分离出的广泛耐药菌复合体的出现。
Vet World. 2022 Jan;15(1):55-64. doi: 10.14202/vetworld.2022.55-64. Epub 2022 Jan 18.
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Virulent and Multiple Antimicrobial Resistance Aeromonas hydrophila Isolated from Diseased Nile Tilapia Fish (Oreochromis niloticus) in Egypt with Sequencing of Some Virulence-Associated Genes.从埃及患病尼罗罗非鱼（Oreochromis niloticus）中分离出的具有毒力和多重抗药性的嗜水气单胞菌，对一些与毒力相关的基因进行了测序。
Biocontrol Sci. 2021;26(3):167-176. doi: 10.4265/bio.26.167.
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Prevalence, Virulence Gene Distribution and Alarming the Multidrug Resistance of Associated with Disease Outbreaks in Freshwater Aquaculture.淡水养殖中与疾病暴发相关的流行情况、毒力基因分布及多重耐药性警示
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Antibiotics and Food Safety in Aquaculture.抗生素与水产养殖中的食品安全
J Agric Food Chem. 2020 Oct 28;68(43):11908-11919. doi: 10.1021/acs.jafc.0c03996. Epub 2020 Oct 4.