Rezkalla Abraam, Rajab Islam, Orhun Nagihan, Saife Sarah, Rjoub Yasmin
Internal Medicine Resident Saint Joseph University Medical Center Paterson New Jersey USA.
Department of Medicine, Faculty of Medicine and Health Sciences An-Najah National University Nablus Palestine.
Clin Case Rep. 2025 Sep 21;13(9):e70903. doi: 10.1002/ccr3.70903. eCollection 2025 Sep.
Primary choriocarcinoma in males is an uncommon and aggressive subtype of germ cell tumors characterized by an early rise in human chorionic gonadotropin (hCG). While testicular cancers are the most common type of solid cancers among young males, almost half of the primary choriocarcinomas diagnosed have metastasized to lymph nodes, lungs, or liver at the time of presentation. Here we present two cases describing two middle-aged men diagnosed with advanced malignancy of primary choriocarcinoma.
男性原发性绒毛膜癌是一种罕见且侵袭性强的生殖细胞肿瘤亚型,其特征是人类绒毛膜促性腺激素(hCG)早期升高。虽然睾丸癌是年轻男性中最常见的实体癌类型,但几乎一半被诊断出的原发性绒毛膜癌在确诊时已转移至淋巴结、肺或肝脏。在此,我们报告两例病例,描述两名中年男性被诊断为原发性绒毛膜癌晚期恶性肿瘤。