Han Xiao, Tang Renzhe, Wang Peng, Liu Li
Department of Oncology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang, China.
The First Department of Cardiovascular, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang, China.
Open Life Sci. 2025 Sep 8;20(1):20251089. doi: 10.1515/biol-2025-1089. eCollection 2025.
The Latin scientific name of turmeric is L., and it belongs to the Zingiberaceae plant family. Curcumin is a yellow compound extracted from the rhizomes of turmeric, known for its various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. This study presents a comprehensive review of the relationship between curcumin and the immune response in breast cancer (BC). Specific therapeutic approaches of curcumin for BC treatment are summarized. The anti-tumor activity of curcumin has garnered significant attention, with unique immunomodulatory effects on inhibiting cancer cell proliferation, inducing autophagy, affecting the cell cycle, and regulating cell apoptosis. Curcumin enhances immune cell-mediated actions against cancer cells through modulation of immune response pathways, alteration of the tumor microenvironment, and influencing immune cell function. Curcumin, via multiple pathways such as anti-inflammatory, antioxidant, apoptosis-inducing, and immunomodulatory effects, holds important clinical value in BC therapy.
姜黄的拉丁学名是L.，它属于姜科植物家族。姜黄素是从姜黄根茎中提取的一种黄色化合物，以其多种生物活性而闻名，包括抗氧化、抗炎和抗癌特性。本研究全面综述了姜黄素与乳腺癌（BC）免疫反应之间的关系。总结了姜黄素治疗BC的具体治疗方法。姜黄素的抗肿瘤活性已引起广泛关注，它对抑制癌细胞增殖、诱导自噬、影响细胞周期和调节细胞凋亡具有独特的免疫调节作用。姜黄素通过调节免疫反应途径、改变肿瘤微环境和影响免疫细胞功能，增强免疫细胞介导的抗癌细胞作用。姜黄素通过抗炎、抗氧化、诱导凋亡和免疫调节等多种途径，在BC治疗中具有重要的临床价值。
