Flores Edmundo Rinolino Magalhães, Cruz Breno Fiuza, Mantovani Lucas Machado, Salgado João Vinicius
Universidade Federal de Minas Gerais, Departamento de Morfologia, Belo Horizonte MG, Brazil.
Universidade Federal de Minas Gerais, Departamento de Saúde Mental, Belo Horizonte MG, Brazil.
Dement Neuropsychol. 2025 Sep 19;19:e20250296. doi: 10.1590/1980-5764-DN-2025-0296. eCollection 2025.
Schizophrenia is a complex psychiatric disorder characterized by positive and negative symptoms, as well as cognitive deficits, with an impact on functioning.
To investigate the relationship between symptomatic remission, cognition, and functioning patients with schizophrenia, based on the criteria of the Remission in Schizophrenia Working Group, and to examine whether achieving remission reflects functional recovery.
The search was conducted in the United States National Library of Medicine (PubMed) and (BVS) databases, covering observational studies published between 2014 and 2023, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
After screening, 23 studies were included. The results indicated that remission is associated with better cognitive performance - such as memory, attention, processing speed, and flexibility - and functional outcomes.
These findings reinforce the importance of consistent criteria for comparisons across studies and clinical practice. Remission is a desired outcome for many patients. However, given the current treatment resources, it remains an objective that only a limited number truly achieve. Investigating its influence is essential for developing more effective interventions.
精神分裂症是一种复杂的精神障碍，其特征为阳性和阴性症状以及认知缺陷，对功能产生影响。
根据精神分裂症缓解工作组的标准，研究精神分裂症患者症状缓解、认知与功能之间的关系，并探讨实现缓解是否反映功能恢复。
检索美国国立医学图书馆（PubMed）和（BVS）数据库，涵盖2014年至2023年发表的观察性研究，遵循系统评价和Meta分析的首选报告项目（PRISMA）。
筛选后纳入23项研究。结果表明，缓解与更好的认知表现（如记忆、注意力、处理速度和灵活性）以及功能结局相关。
这些发现强化了跨研究和临床实践进行比较时采用一致标准的重要性。缓解是许多患者期望的结果。然而，鉴于目前的治疗资源，只有少数患者真正实现缓解仍是一个目标。研究其影响对于开发更有效的干预措施至关重要。
