Smith A R, Rosen I I, Hogstrom K R, Lane R G, Kelsey C A
Med Phys. 1977 Sep-Oct;4(5):408-13. doi: 10.1118/1.594326.
Cellular, animal, and human radiobiology studies are in progress at the Los Alamos Meson Physics Facility as part of a joint University of New Mexico and Los Alamos Scientific Laboratory pion therapy project. To support these activities, dosimetry has been performed on many different pion beam configurations. The effect of both static and dynamic momentum spreaders and of collimators on beam profiles, depth-dose distributions, and peak-to-plateau ratios have been studied. The absorbed dose is obtained by the application of Bragg-Gray cavity theory to ionization chamber measurements. Calculations have been made for the effective W values and average mass-stopping-power ratios needed for the Bragg-Gray equation. Kerma corrections are applied to transform the dose from the chamber wall to dose in muscle.
作为新墨西哥大学和洛斯阿拉莫斯科学实验室联合开展的π介子治疗项目的一部分,细胞、动物和人体放射生物学研究正在洛斯阿拉莫斯介子物理设施进行。为支持这些活动,已对多种不同的π介子束配置进行了剂量测定。研究了静态和动态动量扩展器以及准直器对束流剖面、深度剂量分布和峰坪比的影响。通过将布拉格 - 格雷空腔理论应用于电离室测量来获得吸收剂量。已针对布拉格 - 格雷方程所需的有效W值和平均质量阻止本领比进行了计算。应用比释动能校正将剂量从室壁转换为肌肉中的剂量。