Rajput Sanjna, Vierkant Robert A, Larson Nicole L, Stan Daniela L, Mussallem Dawn M, D'Andre Stacy D, Couch Fergus J, Olson Janet E, O'Sullivan Ciara C, Ruddy Kathryn J
Mayo Clinic School of Graduate Medical Education, Internal Medicine Residency, Mayo Clinic, Rochester, MN, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
J Cancer Surviv. 2025 Sep 24. doi: 10.1007/s11764-025-01893-3.
To evaluate alcohol intake patterns, and identify factors associated with alcohol use in early survivorship among breast cancer survivors, as well as associations with changes in alcohol consumption in early survivorship.
Patients diagnosed with breast cancer (stages 0-3) between 2014 and 2022 were surveyed regarding their average alcohol intake near the time of diagnosis and at approximately one year post-diagnosis. Alcohol intake was categorized into four levels and associations with demographic, clinical, and behavioral factors were assessed using bivariable and multivariable models. Changes in alcohol intake over time were examined using McNemar's and Bowker's tests and multinomial logistic regression.
In this cohort of 2080 participants, the proportion of participants consuming at least one drink per week decreased from 71.2% at diagnosis to 39.8% at one year post-diagnosis, while the proportion reporting less than one drink per week increased from 28.9 to 60.2%. Reduction in alcohol intake at one year post-diagnosis was more likely among those experiencing financial difficulty, receiving chemotherapy, reporting lower physical health, and current or never smokers compared to former smokers. Better physical health, engagement in moderate-intensity exercise, and current smoking were associated with higher cross-sectional alcohol intake at one year post-diagnosis.
Alcohol consumption declined significantly in early survivorship. Financial, behavioral, and treatment-related factors played key roles in shaping these patterns.
Our findings underscore the importance of targeted interventions to support personalized counseling on alcohol intake, particularly for individuals with better physical health, greater financial stability, or co-occurring risky behaviors like smoking.
评估饮酒模式，确定乳腺癌幸存者早期生存阶段与饮酒相关的因素，以及与早期生存阶段饮酒量变化的关联。
对2014年至2022年间诊断为乳腺癌（0 - 3期）的患者进行调查，了解其诊断时及诊断后约一年时的平均饮酒量。饮酒量分为四个等级，并使用双变量和多变量模型评估其与人口统计学、临床和行为因素的关联。使用麦克尼马尔检验和鲍克检验以及多项逻辑回归分析饮酒量随时间的变化。
在这2080名参与者的队列中，每周至少饮用一杯酒的参与者比例从诊断时的71.2%降至诊断后一年时的39.8%，而每周饮酒少于一杯的参与者比例从28.9%增至60.2%。与曾经吸烟者相比，在诊断后一年饮酒量减少的情况在经历经济困难、接受化疗、身体健康状况较差以及目前吸烟或从不吸烟的人群中更为常见。身体健康状况较好、进行中等强度运动以及目前吸烟与诊断后一年的横断面饮酒量较高有关。
在早期生存阶段，饮酒量显著下降。经济、行为和治疗相关因素在形成这些模式中起关键作用。
我们的研究结果强调了有针对性干预措施的重要性，以支持关于饮酒量的个性化咨询，特别是对于身体健康状况较好、经济稳定性较高或同时存在吸烟等危险行为的个体。
