Balbaba Mehmet, Ulaş Fatih, Canleblebici Mehmet, Güven Ozan, Aşcı Toraman Zülal, Yıldırım Hakan, Erdağ Murat
Department of Ophthalmology, Faculty of Medicine, Fırat University, Elazığ 23119, Türkiye.
Department of Ophthalmology, Faculty of Medicine, Abant Izzet Baysal University, Bolu 14030, Türkiye.
Int J Ophthalmol. 2025 Oct 18;18(10):1846-1850. doi: 10.18240/ijo.2025.10.04. eCollection 2025.
To assess and compare the conjunctival bacterial flora in patients with congenital ptosis (CP) to that of healthy individuals.
The study included 38 patients with CP and 42 healthy control subjects. Conjunctival cultures were collected using a cotton-tipped swab applied to the inferior conjunctival fornix. The samples were inoculated into blood agar, eosin methylene blue agar, chocolate agar for bacteria, and Sabouraud dextrose agar medium for fungi.
The culture positivity rate was 68.4% in CP and 47.6% in the control group (<0.001). Additionally, there was a significant difference in culture positivity between the eyes of patients with unilateral ptosis (=0.039). In the CP group, the most common found microorganism was at 23.67%, followed by at 21.04%, and at 15.78%. In the control group, and were both the most commonly isolated microorganisms, each accounting for 19.04%. More than one species of bacteria was grown in the cultures of 36.84% and 23.80% of the CP and control subjects, respectively. Gram-negative bacteria were more common in CP than in control subjects (=0.031).
Culture positivity is significantly higher in the ptotic eyes of CP. Potentially pathogenic microorganisms are more frequently isolated from the CP group compared with the healthy control group.
评估并比较先天性上睑下垂（CP）患者与健康个体的结膜细菌菌群。
该研究纳入了38例CP患者和42名健康对照者。使用棉签蘸取下结膜穹窿处的样本进行结膜培养。将样本接种于血琼脂、伊红美蓝琼脂、用于细菌培养的巧克力琼脂以及用于真菌培养的沙氏葡萄糖琼脂培养基。
CP组的培养阳性率为68.4%，对照组为47.6%（<0.001）。此外，单侧上睑下垂患者两眼之间的培养阳性率存在显著差异（=0.039）。在CP组中，最常见的微生物是[具体微生物名称1]，占23.67%，其次是[具体微生物名称2]，占21.04%，[具体微生物名称3]占15.78%。在对照组中，[具体微生物名称4]和[具体微生物名称5]均为最常分离出的微生物，各占19.04%。CP组和对照组分别有36.84%和23.80%的受试者培养出不止一种细菌。CP组中革兰氏阴性菌比对照组更常见（=0.031）。
CP患者上睑下垂眼的培养阳性率显著更高。与健康对照组相比，CP组更频繁地分离出潜在致病微生物。
