Bouchelkia Iman, Tyring Stephen
Biomedical Sciences, Tilman J. Fertitta Family College of Medicine, Houston, USA.
Dermatology, The University of Texas Health Science Center, Houston, USA.
Cureus. 2025 Aug 23;17(8):e90820. doi: 10.7759/cureus.90820. eCollection 2025 Aug.
Topical isotretinoin is designed to work locally on the skin with limited systemic absorption and is being explored as a potential alternative to more commonly used topical retinoids. However, limited research, formulation challenges, and regulatory hurdles have slowed its path to widespread use. It appears to perform similarly to other topical retinoids and may offer added benefits such as improved tolerability and greater formulation stability. Additionally, its ability to integrate into combination therapies may further enhance its clinical utility. Despite these benefits, the lack of extensive randomized controlled trials limits understanding of its optimal use, long-term effects, and safety profile. Future research is essential to determine its role in dermatologic treatment, but its potential to expand therapeutic options remains promising.
外用异维A酸旨在局部作用于皮肤，全身吸收有限，目前正被探索作为更常用外用维甲酸的潜在替代品。然而，研究有限、制剂挑战和监管障碍减缓了其广泛应用的进程。它的表现似乎与其他外用维甲酸相似，可能具有一些额外的益处，如耐受性更好和制剂稳定性更高。此外，它融入联合疗法的能力可能会进一步提高其临床效用。尽管有这些益处，但缺乏广泛的随机对照试验限制了我们对其最佳用法、长期效果和安全性的了解。未来的研究对于确定其在皮肤病治疗中的作用至关重要，但其扩大治疗选择的潜力仍然很有前景。
