Lu Qian, Cao Cunwei, Liang Jiarong, Su Jiaguang
Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, CHN.
Cureus. 2025 Aug 24;17(8):e90878. doi: 10.7759/cureus.90878. eCollection 2025 Aug.
Erythema elevatum diutinum (EED) is an uncommon, chronic form of cutaneous leukocytoclastic vasculitis that typically manifests as purplish-red to reddish-brown nodules, papules, or plaques, predominantly on the extensor surfaces. We report a rare case of bullous EED in a 67-year-old Chinese woman, whose condition included an unusual blistering presentation. The diagnosis was confirmed through histopathological examination. Upon diagnosis, the patient was treated with a combination of oral prednisone, thalidomide, and local infiltration therapy with triamcinolone acetonide, which led to significant clinical improvement. This case is noteworthy for its atypical presentation and its broader implications for the diagnosis and management of similar cases.
持久性隆起性红斑（EED）是一种罕见的慢性皮肤白细胞破碎性血管炎，通常表现为紫红色至红棕色结节、丘疹或斑块，主要出现在伸侧表面。我们报告了一例67岁中国女性的大疱性EED罕见病例，其病情包括不寻常的水疱表现。通过组织病理学检查确诊。确诊后，患者接受了口服泼尼松、沙利度胺和曲安奈德局部浸润治疗的联合治疗，临床症状有显著改善。该病例因其非典型表现以及对类似病例诊断和管理的更广泛意义而值得关注。
