Sutanto Ratna, Muchtar Yarmaniani Miliati, Bramantya Ido Narpati, Haezer Randi Eben, Christanti Jessica
Radiology Department, Medical Faculty, Pelita Harapan University, Tangerang, Indonesia.
Radiology Department, National Women and Children Health Center Harapan Kita, Jakarta, Indonesia.
Childs Nerv Syst. 2025 Sep 25;41(1):291. doi: 10.1007/s00381-025-06939-6.
This study presents a case series of two neonates with interhemispheric cysts and corpus callosum dysgenesis, complemented by a systematic review of 48 cases, to characterize prenatal MRI features and their correlations with postnatal imaging findings and surgical outcomes.
Two neonates were prenatally diagnosed with interhemispheric cysts. In both cases, postnatal imaging was performed, followed by implantation of a cystoperitoneal shunt (CPS). We conducted a systematic review of 48 cases to analyze the imaging findings, associated anomalies, and surgical outcomes.
Prenatal MRI revealed interhemispheric cysts, colpocephaly, and corpus callosum dysgenesis in both cases, with progressive cyst enlargement during gestation. These findings were confirmed by postnatal imaging. CPS implantation reduced intracranial pressure but was associated with complications such as shunt blockage and increased cyst size. Complications were more common in patients with complex cyst morphology on MRI. Endoscopic cystoventriculostomy showed better outcomes for multiseptate cysts, whereas shunt-based procedures were associated with more complications but remained necessary in complex or refractory cases.
Prenatal MRI is invaluable for the early detection of interhemispheric cysts and corpus callosum dysgenesis, enabling tailored postnatal intervention. Although CPS is effective in managing hydrocephalus, endoscopic cystoventriculostomy may offer better outcomes in reducing cyst size and preventing recurrence. This study underscores the importance of integrating prenatal imaging into clinical practice to optimize surgical planning and improve long-term neurodevelopmental outcomes.
本研究报告了两例患有半球间囊肿和胼胝体发育不全的新生儿病例系列，并对48例病例进行了系统回顾，以描述产前MRI特征及其与产后影像学检查结果和手术结果的相关性。
两名新生儿在产前被诊断出患有半球间囊肿。在这两例病例中，均进行了产后影像学检查，随后植入了囊肿腹腔分流管（CPS）。我们对48例病例进行了系统回顾，以分析影像学检查结果、相关异常情况和手术结果。
产前MRI显示两例病例均有半球间囊肿、脑室扩张和胼胝体发育不全，孕期囊肿逐渐增大。这些结果在产后影像学检查中得到证实。CPS植入降低了颅内压，但与分流堵塞和囊肿增大等并发症相关。MRI显示囊肿形态复杂的患者并发症更为常见。内镜下囊肿脑室造瘘术对多房性囊肿显示出更好的效果，而基于分流的手术并发症更多，但在复杂或难治性病例中仍然必要。
产前MRI对于早期发现半球间囊肿和胼胝体发育不全非常重要，能够进行针对性的产后干预。虽然CPS在治疗脑积水方面有效，但内镜下囊肿脑室造瘘术在减小囊肿大小和预防复发方面可能会有更好的效果。本研究强调了将产前影像学检查纳入临床实践以优化手术规划和改善长期神经发育结果的重要性。
