普鲁卡因酰胺治疗患者血清中抗核抗体的发生率、免疫球蛋白模式及特异性
Occurrence, immunoglobulin pattern and specificity of antinuclear antibodies in sera of procaine amide treated patients.
作者信息
Klajman A, Camin-Belsky N, Kimchi A, Ben-Efraim S
出版信息
Clin Exp Immunol. 1970 Nov;7(5):641-9.
Abstract
Thirty-one out of fifty patients receiving procaine amide were found to develop antinuclear antibodies belonging in most cases to the IgM and IgG classes and to a lesser extent to the IgA class. Specific interaction between these antibodies and a nucleoprotein component could be demonstrated in a large proportion of cases. No relation was found between occurrence of antinuclear antibodies and development of an immune response to procaine amide itself.
摘要
在接受普鲁卡因酰胺治疗的50名患者中，有31人被发现产生了抗核抗体，这些抗体在大多数情况下属于IgM和IgG类，在较小程度上属于IgA类。在大部分病例中都能证明这些抗体与一种核蛋白成分之间存在特异性相互作用。未发现抗核抗体的出现与对普鲁卡因酰胺自身的免疫反应的发生之间存在关联。
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