Ammann A J, Hong R
Clin Exp Immunol. 1970 Dec;7(6):833-8.
Laboratory and clinical data are presented in fifteen patients under the age of sixteen years with selective IgA deficiency, all of whom had normal serum IgG, IgM, IgD and IgE. Results indicate a high incidence of autoimmune disease, autoimmune phenomenon or unusual antibody formation. Three patients had thyroiditis, one cerebral vasculitis, one pulmonary haemosiderosis, one cystic fibrosis and nine had recurrent upper respiratory tract infections. Ten out of fifteen were positive for one or more `autoantibodies.' Selective IgA deficiency cannot always be considered a benign entity and individuals with this defect warrant complete investigation.
本文呈现了15名16岁以下选择性IgA缺乏患者的实验室检查和临床数据，所有患者血清IgG、IgM、IgD和IgE均正常。结果显示自身免疫性疾病、自身免疫现象或异常抗体形成的发生率较高。3例患者患有甲状腺炎，1例患有脑血管炎，1例患有肺含铁血黄素沉着症，1例患有囊性纤维化，9例反复出现上呼吸道感染。15例中有10例一种或多种“自身抗体”呈阳性。选择性IgA缺乏不能总是被视为一种良性疾病，患有这种缺陷的个体需要进行全面检查。
