家兔的松果体实质肿瘤。
Pineal parenchymal tumor in a domestic rabbit.
作者信息
Crakes Katti R, Eberhart Charles G, Flanders John A, Trupkiewicz John G
机构信息
Departments of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
J Vet Diagn Invest. 2025 Sep 25:10406387251371014. doi: 10.1177/10406387251371014.
An 11-y-old male lionhead rabbit () was presented with progressive hindlimb weakness and right-sided neurologic deficits, and was subsequently euthanized due to poor prognosis. Autopsy revealed a 1.6 × 1.1 × 1.0-cm, well-circumscribed, extra-axial mass compressing the occipital lobe and affecting both telencephalic hemispheres. Histologic and immunohistochemical analyses demonstrating positivity for synaptophysin and neuron-specific enolase, along with a Ki67 proliferative index of ~20%, were highly suggestive of a high-grade pineal parenchymal tumor (PPT). The tumor was densely cellular with marked atypia and frequent binucleation, and lacked pineocytomatous rosettes-features most consistent with a pineal parenchymal tumor of intermediate differentiation in humans. No evidence of metastasis was observed. Pineal tumors are exceptionally rare in domestic animals, with limited documentation in species such as dogs, horses, goats, cattle, and birds. To our knowledge, PPT has not been reported previously in a rabbit, underscoring the diagnostic challenges associated with intracranial neoplasms in this species.
一只11岁的雄性狮子头兔出现进行性后肢无力和右侧神经功能缺损，随后因预后不良而实施安乐死。尸检发现一个1.6×1.1×1.0厘米、边界清楚的轴外肿块，压迫枕叶并影响双侧大脑半球。组织学和免疫组化分析显示突触素和神经元特异性烯醇化酶呈阳性，Ki67增殖指数约为20%，高度提示为高级别松果体实质肿瘤（PPT）。肿瘤细胞密集，具有明显异型性且双核常见，缺乏松果细胞瘤性菊形团——这是与人类中间分化松果体实质肿瘤最相符的特征。未观察到转移迹象。松果体肿瘤在家畜中极为罕见，在犬、马、山羊、牛和鸟类等物种中的记录有限。据我们所知，此前尚未有兔子发生PPT的报道，这凸显了该物种颅内肿瘤相关的诊断挑战。
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