Zagzag D, Brem S, Robert F
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Am J Pathol. 1988 May;131(2):361-72.
A model for the study of tumor angiogenesis within the rabbit brain is presented. Implantation of the VX2 carcinoma provides a reproducible tumor accompanied by angiogenesis. The authors report the sequential growth, histology, tumor neovascularization, and vascular permeability of this tumor following its intracerebral implantation. Tumor angiogenesis correlates with the rapid and logarithmic intracerebral tumor growth. The proliferation of blood vessels in the tumor and the organization of tumor cells around tumor vessels are described. Breakdown of the blood-brain barrier (detected by Evans blue leakage) starts in the early stages of tumor development and becomes prominent as the tumor vasculature and size increase. This model is useful for experimental studies of angiogenesis.
本文提出了一种用于研究兔脑内肿瘤血管生成的模型。植入VX2癌可产生伴有血管生成的可重复性肿瘤。作者报告了该肿瘤脑内植入后的序贯生长、组织学、肿瘤新生血管形成及血管通透性。肿瘤血管生成与脑内肿瘤的快速对数生长相关。描述了肿瘤内血管的增殖以及肿瘤细胞围绕肿瘤血管的组织情况。血脑屏障的破坏（通过伊文思蓝渗漏检测）在肿瘤发展的早期阶段开始，并随着肿瘤血管系统和大小的增加而变得显著。该模型对于血管生成的实验研究很有用。
