Jha Saurav, Phillips Emilee, Safran Martin Jumbelic, Gupta Saurabh
Department of Radiology Patan Academy of Health Sciences Kathmandu Nepal.
Department of Radiology SUNY Upstate Medical University Hospital New York USA.
Clin Case Rep. 2025 Sep 24;13(10):e70939. doi: 10.1002/ccr3.70939. eCollection 2025 Oct.
Yolk sac tumor, also referred to as endodermal sinus tumor, is an aggressive malignant germ cell neoplasm that most commonly originates in the gonad. Its occurrence in extra-gonadal sites is infrequent and is highly malignant, with only a handful of cases reported in the literature. With the help of this article, we want to make readers aware of the rare site of yolk sac tumor, its clinical presentation, and its radiological findings. As clinicians, we should be vigilant to consider differential diagnoses for an underlying etiology, like yolk sac tumor, for a patient presenting with a subcutaneous lump. Even though swelling in subcutaneous regions, in most cases, represents a benign diagnosis, malignant ones should always be kept in the back of the mind while managing patients. Variation in the site of extragonadal germ cell tumors has been highlighted with this paper, and herein, we aim to make readers aware of a rare and uncommon germ cell tumor, acknowledging the importance of imaging findings in making a diagnosis and the approach for its management.
卵黄囊瘤，也称为内胚窦瘤，是一种侵袭性恶性生殖细胞肿瘤，最常见于性腺。其发生于性腺外部位的情况并不常见，且恶性程度很高，文献中仅报道了少数病例。借助本文，我们希望让读者了解卵黄囊瘤的罕见发病部位、临床表现及其影像学表现。作为临床医生，对于出现皮下肿块的患者，我们应警惕考虑潜在病因（如卵黄囊瘤）的鉴别诊断。尽管皮下区域的肿胀在大多数情况下代表良性诊断，但在治疗患者时，始终应牢记恶性情况。本文强调了性腺外生殖细胞肿瘤发病部位的差异，在此，我们旨在让读者了解一种罕见且不常见的生殖细胞肿瘤，认识到影像学表现在诊断中的重要性及其治疗方法。
