Shrestha Palpasa, Wen Zhi, Zheng Anyuan, Yang Xilin, Liao Hua, Ramjaun Mohamed Muntasir, You Cixing, Shrestha Jati, Yang Renjie, Chen Jun
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Front Neurol. 2025 Sep 10;16:1647804. doi: 10.3389/fneur.2025.1647804. eCollection 2025.
Sudden sensorineural hearing loss (SSNHL) rapidly decreases hearing, often by more than 30 decibels within 3 days. While circulatory issues are suspected causes, the exact reason remains unclear. This study employs Arterial Spin Labeling to examine changes in cerebral blood flow and its relationship with hydration levels in SSNHL.
A prospective study examined patients with SSNHL, dividing them into 20 right-sided SSNHL (RSSNHL), 22 left-sided SSNHL (LSSNHL), and 20 healthy controls (HC). Cerebral blood flow (CBF) data were obtained using MATLAB. Statistical analysis included one-way ANOVA with analysis among RSSNHL, LSSNHL, HC, and Pearson correlation to explore the relationship with clinical variables.
Compared to HC, patients with RSSNHL showed reduced CBF value in right medial superior frontal gyrus, Heschl's gyrus (HG), and left inferior temporal gyrus, conversely increased perfusion in left calcarine. In LSSNHL patients, CBF value was decreased in the left superior temporal gyrus (STG) and right middle temporal gyrus, with increased perfusion in the left temporal pole STG compared to HC (cluster level < 0.05 after FDR correction). Furthermore, CBF in the right HG of RSSNHL and left STG of LSSNHL negatively correlated with blood viscosity ( = -0.621, = 0.003; = -0.560, = 0.007) and urine specific gravity ( = -0.483, = 0.031; = -0.485, = 0.022), and positively correlated with daily water intake ( = 0.650, = 0.002; = 0.568, = 0.006).
Cerebral perfusion changes were present in the temporal, frontal, and occipital lobes of SSNHL patients. Furthermore, insufficient water intake may be a potential cause of SSNHL. Drinking adequate water is vital in preventing and recovering from this condition.
突发性感音神经性听力损失（SSNHL）会迅速导致听力下降，通常在3天内下降超过30分贝。虽然循环系统问题被怀疑是病因，但确切原因仍不清楚。本研究采用动脉自旋标记法来研究SSNHL患者脑血流的变化及其与水合水平的关系。
一项前瞻性研究对SSNHL患者进行了检查，将他们分为20例右侧SSNHL（RSSNHL）、22例左侧SSNHL（LSSNHL）和20例健康对照者（HC）。使用MATLAB获取脑血流（CBF）数据。统计分析包括对RSSNHL、LSSNHL、HC进行单因素方差分析以及Pearson相关性分析，以探讨其与临床变量的关系。
与HC相比，RSSNHL患者右侧额上回内侧、颞横回（HG）和左侧颞下回的CBF值降低，相反，左侧距状裂的灌注增加。在LSSNHL患者中，左侧颞上回（STG）和右侧颞中回的CBF值降低，与HC相比，左侧颞极STG的灌注增加（经FDR校正后聚类水平<0.05）。此外，RSSNHL右侧HG和LSSNHL左侧STG的CBF与血液粘度呈负相关（r = -0.621，P = 0.003；r = -0.560，P = 0.007）以及与尿比重呈负相关（r = -0.483，P = 0.031；r = -0.485，P = 0.022），并且与每日饮水量呈正相关（r = 0.650，P = 0.002；r = 0.568，P = 0.006）。
SSNHL患者的颞叶、额叶和枕叶存在脑灌注变化。此外，水分摄入不足可能是SSNHL的一个潜在原因。饮用足够的水对于预防和从这种疾病中恢复至关重要。
