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以岩藻糖基化硫酸软骨素为原料的可植入生物可吸收支架作为延迟刺激造血的有前景装置

Implantable Bioresorbable Scaffold with Fucosylated Chondroitin Sulfate as a Promising Device for Delayed Stimulation of Hematopoiesis.

作者信息

Anisimova Natalia Y, Rybalchenko Olga V, Martynenko Natalia S, Rybalchenko Georgy V, Lukyanova Elena A, Bilan Maria I, Usov Anatolii I, Kiselevskiy Mikhail V, Nifantiev Nikolay E

机构信息

N.N. Blokhin National Medical Research Center of Oncology (N.N. Blokhin NMRCO) of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.

A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, 119334 Moscow, Russia.

出版信息

Mar Drugs. 2025 Aug 28;23(9):344. doi: 10.3390/md23090344.

DOI:10.3390/md23090344
PMID:41003313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12471459/
Abstract

The aim of this study was to evaluate the prospects of using natural fucosylated chondroitin sulfate (FCS) from the sea cucumber as the active component of an implantable biodegradable scaffold to stimulate hematopoiesis in mice with cyclophosphamide (CPh)-induced myelosuppression. The scaffolds were based on bioresorbable Fe-Mn-C and Fe-Mn-Pd alloys after equal-channel angular pressing (ECAP). The efficiency of the developed constructs with FCS was compared with the activity of the same scaffolds loaded with recombinant human granulocyte colony stimulating factor, as well as solutions of these active compounds administered subcutaneously after the end of the cyclophosphamide (CPh) course. It was found that implantation of the Fe-Mn-C scaffold loaded with FCS most effectively stimulated hematopoiesis, providing a complex effect. This design of the developed constructs contributed to an increase in the concentration not only of leukocytes and neutrophils, but also platelets in the blood, promoted the proliferation of bone marrow cells, increasing the concentration of Ki-67(+) cells, and contributed to the restoration of the morphology of the animals' spleen.

摘要

本研究的目的是评估使用海参中的天然岩藻糖基化硫酸软骨素（FCS）作为可植入生物可降解支架的活性成分，以刺激环磷酰胺（CPh）诱导的骨髓抑制小鼠造血的前景。该支架基于等通道转角挤压（ECAP）后的生物可吸收Fe-Mn-C和Fe-Mn-Pd合金。将含有FCS的已开发构建体的效率与负载重组人粒细胞集落刺激因子的相同支架的活性进行比较，并将这些活性化合物的溶液在环磷酰胺（CPh）疗程结束后皮下给药。结果发现，植入负载FCS的Fe-Mn-C支架最有效地刺激了造血，产生了综合效应。所开发构建体的这种设计不仅有助于提高血液中白细胞、中性粒细胞的浓度，还能提高血小板的浓度，促进骨髓细胞增殖，增加Ki-67（+）细胞的浓度，并有助于恢复动物脾脏的形态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/391f1e2a44e2/marinedrugs-23-00344-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/2ca1fa229f52/marinedrugs-23-00344-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/6a78bccc24a5/marinedrugs-23-00344-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/fac7b3a7ae61/marinedrugs-23-00344-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/52b40033c865/marinedrugs-23-00344-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/1b577d6d5ba2/marinedrugs-23-00344-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/cd9db1e7cf4b/marinedrugs-23-00344-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/3ebbe41f40a5/marinedrugs-23-00344-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/391f1e2a44e2/marinedrugs-23-00344-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/2ca1fa229f52/marinedrugs-23-00344-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/6a78bccc24a5/marinedrugs-23-00344-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/fac7b3a7ae61/marinedrugs-23-00344-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/52b40033c865/marinedrugs-23-00344-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/1b577d6d5ba2/marinedrugs-23-00344-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/cd9db1e7cf4b/marinedrugs-23-00344-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/3ebbe41f40a5/marinedrugs-23-00344-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e55d/12471459/391f1e2a44e2/marinedrugs-23-00344-g008.jpg

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