N.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Kashirskoe Shosse, 24, 115478 Moscow, Russia.
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, 119991 Moscow, Russia.
Mar Drugs. 2017 Sep 30;15(10):301. doi: 10.3390/md15100301.
Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed () and fucosylated chondroitin sulfate from the sea cucumber (), were studied as stimulators of hematopoiesis after cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor () was applied as a reference. Both tested polysaccharides and have a similar activity to , causing pronounced neutropoiesis stimulation in animals with myelosuppression induced by cyclophosphamide (). Moreover, these compounds are also capable to enhance thrombopoiesis and erythropoiesis. It should be noted that demonstrated a greater activity than . The results indicate the perspective of further studies of and , since these compounds can be considered as potentially promising stimulators of hematopoiesis. Such drugs are in demand for the accompanying treatment of cancer patients who suffer from hematological toxicity during chemo and/or radiation therapy.
细胞抑制剂在癌症患者的化疗中的应用会导致许多副作用，包括对各种造血部分的抑制。两种硫酸化多糖，来自海藻的褐藻糖胶（fucoidan）和来自海参的岩藻依聚糖硫酸酯（fucosylated chondroitin sulfate），被研究作为环磷酰胺免疫抑制后小鼠造血的刺激物。重组粒细胞集落刺激因子（recombinant granulocyte colony-stimulating factor）被用作参考。两种测试多糖和都具有与相似的活性，在环磷酰胺诱导的骨髓抑制动物中引起明显的嗜中性粒细胞刺激作用（）。此外，这些化合物还能够增强血小板生成和红细胞生成。值得注意的是，表现出比更大的活性。这些结果表明了进一步研究和的前景，因为这些化合物可以被认为是具有潜在前景的造血刺激物。这些药物在癌症患者的伴随治疗中是有需求的，这些患者在化疗和/或放疗期间会遭受血液毒性。
