Pesce Giovanna, Sartoretto Suelen Cristina, Resende Rodrigo Figueiredo de Brito, Silva Madelaine Torres da, Granjeiro Jose Mauro, Del Fabbro Massimo, Mourão Carlos Fernando, Calasans-Maia Monica
Post-Graduation Program in Dentistry, Fluminense Federal University, Niteroi 24220-140, Brazil.
Oral Surgery Department, Fluminense Federal University, Niteroi 24220-140, Brazil.
J Funct Biomater. 2025 Aug 22;16(9):305. doi: 10.3390/jfb16090305.
Adequate bleeding control is crucial in surgical procedures. Surgifoam and Hemospon are absorbable hemostatic sponges made from lyophilized porcine gelatin, commonly used in oral surgery. This clinical study aimed to evaluate bleeding control, soft tissue healing, and postoperative pain in dental sockets after mandibular third molar extractions filled with Surgifoam and Hemospon. Twenty-five volunteers requiring extractions of both left and right lower third molars participated in this randomized, double-blind, split-mouth study. After extraction, each socket was randomly filled with Hemospon (test group) or Surgifoam (control group). Postoperative pain was assessed using the Visual Analog Scale (VAS) on days 1, 2, 3, and 7. Bleeding at 30 and 60 min (Souto and Mühlemann scales) and soft tissue healing at 7 and 14 days (Brancaccio scale) were evaluated using Fisher's exact test. Bleeding scores at 30 min predominantly showed no bleeding (score 0) in 80% of participants using Surgifoam, compared to 60% in the Hemospon group. No significant differences in bleeding were observed between groups ( > 0.05), and both showed a similar reduction over time. Soft tissue healing was revealed at 14 days complete healing (score 0) in 90% of participants in both groups. No significant differences between Hemospon and Surgifoam were observed ( > 0.05). Postoperative pain evaluation showed highly variable scores on the first day (median: 2; range: 1-6) for both Surgifoam and Hemospon. By the seventh day, pain levels significantly reduced (median: 0), with no significant differences observed between the groups at any time point ( > 0.05). In conclusion, the results of this study suggest that Hemospon and Surgifoam are equally effective in bleeding control, healing, and pain control after third molar surgery. This research aims to guide surgeons on the clinical aspects of using these specific hemostatic sponges in post-extraction procedures for posterior molars and seeks to direct future clinical studies involving these materials.
在外科手术中，充分的出血控制至关重要。Surgifoam和Hemospon是由冻干猪明胶制成的可吸收止血海绵，常用于口腔外科手术。这项临床研究旨在评估在下颌第三磨牙拔除术后，使用Surgifoam和Hemospon填充牙槽窝后的出血控制情况、软组织愈合情况及术后疼痛情况。25名需要拔除左右两侧下颌第三磨牙的志愿者参与了这项随机、双盲、口内对照研究。拔牙后，每个牙槽窝随机填充Hemospon（试验组）或Surgifoam（对照组）。术后第1、2、3和7天使用视觉模拟量表（VAS）评估疼痛情况。使用Fisher精确检验评估30分钟和60分钟时的出血情况（Souto和Mühlemann量表）以及第7天和14天时的软组织愈合情况（Brancaccio量表）。在使用Surgifoam的参与者中，80%在30分钟时的出血评分主要显示无出血（评分为0），而在Hemospon组中这一比例为60%。两组之间在出血情况上未观察到显著差异（>0.05），且两者随时间的减少情况相似。两组中90%的参与者在第14天时显示软组织完全愈合（评分为0）。在Hemospon和Surgifoam之间未观察到显著差异（>0.05）。术后疼痛评估显示，Surgifoam和Hemospon在第一天的评分变化很大（中位数：2；范围：1 - 6）。到第7天，疼痛程度显著降低（中位数：0），在任何时间点两组之间均未观察到显著差异（>0.05）。总之，本研究结果表明，Hemospon和Surgifoam在第三磨牙手术后的出血控制、愈合及疼痛控制方面同样有效。本研究旨在为外科医生在拔除后磨牙的拔牙后程序中使用这些特定止血海绵的临床方面提供指导，并寻求指导未来涉及这些材料的临床研究。
