Goethe K E, Isaac W
Pharmacol Biochem Behav. 1977 Jul;7(1):79-82. doi: 10.1016/0091-3057(77)90014-4.
The effects of oral doses of d-amphetamine and methylphenidate on a fixed-interval operant response were studied in four young male squirrel monkeys. A fixed-interval of 80 sec with a limited hold of 20 sec was used. Methylphenidate produced no observable changes in behavior, while d-amphetamine produced dose related changes in both the rate of responding and the temporal patterning of responses. Since dose levels used included, and exceeded, human clinical dosages, the present findings may have implications for future research involving the clinical use of these drugs.
在四只雄性幼年松鼠猴身上研究了口服剂量的右旋苯丙胺和哌甲酯对固定间隔操作性反应的影响。采用了80秒的固定间隔和20秒的有限保持时间。哌甲酯未产生可观察到的行为变化，而右旋苯丙胺则在反应速率和反应的时间模式上产生了与剂量相关的变化。由于所使用的剂量水平包括并超过了人类临床剂量，目前的研究结果可能对未来涉及这些药物临床应用的研究具有启示意义。
