用于再生医学和药物发现应用的大分子拥挤效应
Macromolecular Crowding for Reparative Medicine and Drug Discovery Applications.
作者信息
Giuffredi Giulia, Rossoni Andrea, Cubillo Laura Trujillo, Zeugolis Dimitrios I
机构信息
Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Charles Institute of Dermatology, Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering, University College Dublin (UCD), Dublin, Ireland.
出版信息
Subcell Biochem. 2025;109:433-445. doi: 10.1007/978-3-032-03370-3_19.
Cell-based reparative medicine and drug discovery utilise the innate sophistication of cells to build supramolecular assemblies. Unfortunately, bereft of their optimal tissue context, during in vitro culture, this ability is compromised. Herein, we argue that macromolecular crowding is the missing link in the development of tissue facsimiles for reparative medicine and drug discovery purposes.
基于细胞的再生医学和药物研发利用细胞固有的复杂性来构建超分子组装体。不幸的是，在体外培养过程中，由于缺乏最佳的组织环境，这种能力受到了损害。在此，我们认为大分子拥挤是用于再生医学和药物研发目的的组织模拟物开发中缺失的环节。
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