Macromolecular Crowding for Reparative Medicine and Drug Discovery Applications.
作者信息
Giuffredi Giulia, Rossoni Andrea, Cubillo Laura Trujillo, Zeugolis Dimitrios I
机构信息
Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Charles Institute of Dermatology, Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering, University College Dublin (UCD), Dublin, Ireland.
出版信息
Subcell Biochem. 2025;109:433-445. doi: 10.1007/978-3-032-03370-3_19.
Cell-based reparative medicine and drug discovery utilise the innate sophistication of cells to build supramolecular assemblies. Unfortunately, bereft of their optimal tissue context, during in vitro culture, this ability is compromised. Herein, we argue that macromolecular crowding is the missing link in the development of tissue facsimiles for reparative medicine and drug discovery purposes.
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