Norrby E, Marusyk H, Orvell C
J Virol. 1970 Aug;6(2):237-42. doi: 10.1128/JVI.6.2.237-242.1970.
The structure and morphogenesis of respiratory syncytial (RS) virus particles in a green monkey kidney cell line (Vero) were examined. Infected cells contained dense intracytoplasmic inclusions composed of filamentous structures. In places where inclusion material was associated with membranes, structural modifications were induced. There was a thickening of the membrane and an addition of projections 12 to 15 nm in length. The same changes were most frequently observed after association of isolated filamentous structures with the cytoplasmic membrane. The budding-off process was clearly visualized. The diameter of mature virus particles varied between 90 and 130 nm and that of the internal component varied between 11 and 15 nm. The similarities between ultrastructural features of cells infected with RS virus and pneumonia virus of mice are pointed out. It is proposed that these two viruses should be classified together in a third subgroup of myxoviruses.
对绿猴肾细胞系（Vero）中呼吸道合胞（RS）病毒颗粒的结构和形态发生进行了研究。受感染的细胞含有由丝状结构组成的致密胞质内包涵体。在包涵体物质与膜相关的部位，会诱导结构改变。膜会增厚，并添加长度为12至15纳米的突起。在分离的丝状结构与细胞质膜结合后，最常观察到相同的变化。出芽过程清晰可见。成熟病毒颗粒的直径在90至130纳米之间变化，内部成分的直径在11至15纳米之间变化。指出了感染RS病毒的细胞与小鼠肺炎病毒超微结构特征之间的相似性。建议将这两种病毒一起归为黏液病毒的第三个亚组。
