Wang Jian, Xiao Huihui, Cui Siqian, Wu Chunrong, Xiang Debing
Department of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, PR China; Department of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, PR China.
Department of Oncology, Jiangjin Hospital, School of Medicine, Chongqing University, Chongqing 402260, PR China.
Biochim Biophys Acta Rev Cancer. 2025 Nov;1880(6):189460. doi: 10.1016/j.bbcan.2025.189460. Epub 2025 Sep 24.
Neutrophils play a multifaceted and dynamically evolving role in the progression of inflammation-driven colorectal cancer (CRC). This review summarizes the functional reprogramming and phenotypic polarization of neutrophils under chronic inflammatory conditions, with a particular focus on their contribution to tumor immune microenvironment remodeling. Specifically, we highlight the role of neutrophil extracellular traps (NETs), released through NETosis, in establishing immunosuppressive networks and reshaping the pro-metastatic stromal niche. The review further discusses the reciprocal interactions between neutrophils and the tumor microenvironment, as well as the impact of metabolic reprogramming and gut microbiota crosstalk on inflammation-to-cancer transition. By systematically outlining the mechanisms through which neutrophils influence inflammation-associated CRC, this review aims to provide conceptual insights and a framework for future research and therapeutic intervention strategies.
中性粒细胞在炎症驱动的结直肠癌（CRC）进展中发挥着多方面且动态演变的作用。本综述总结了慢性炎症条件下中性粒细胞的功能重编程和表型极化，特别关注它们对肿瘤免疫微环境重塑的贡献。具体而言，我们强调了通过NETosis释放的中性粒细胞胞外陷阱（NETs）在建立免疫抑制网络和重塑促转移基质微环境中的作用。该综述进一步讨论了中性粒细胞与肿瘤微环境之间的相互作用，以及代谢重编程和肠道微生物群串扰对炎症向癌症转变的影响。通过系统地概述中性粒细胞影响炎症相关CRC的机制，本综述旨在提供概念性见解以及未来研究和治疗干预策略的框架。
