Yu Longhui, Li Shangzhao, Ogawa Hiroshige, Ma Yilin, Chen Qing, Yamazaki Ken, Nagata Yuuya, Nakamura Hugh
The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China.
Okayama University, Tsushimanaka, Okayama, Japan.
Nat Commun. 2025 Sep 26;16(1):8379. doi: 10.1038/s41467-025-63515-x.
A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups, and thus, the development of efficient reactions for their conversion has significant importance in medicinal and process chemistry. Here, we present a redox-neutral Giese reaction via anodic oxidation to generate phosphonium ions in combination with a cathodic reduction to yield low-valent Fe-catalysts. This reaction represents a promising example of a redox-neutral reaction using an Fe-catalyst and electrochemistry. The results obtained in this study will facilitate the exploration of a wide range of novel reactions employing this redox cycle in the future.
报道了一种氧化还原中性的铁电催化脱氧吉泽反应。羟基是最丰富的官能团之一，因此，开发高效的羟基转化反应在药物化学和过程化学中具有重要意义。在此，我们展示了一种氧化还原中性的吉泽反应，通过阳极氧化生成鏻离子，并结合阴极还原生成低价铁催化剂。该反应是使用铁催化剂和电化学的氧化还原中性反应的一个有前景的例子。本研究获得的结果将有助于未来探索利用这种氧化还原循环的广泛新型反应。
