N型钙通道介导小鼠纹状体中依赖刺激的α-突触核蛋白分泌。
N-type Ca channels mediate the stimuli-dependent α-synuclein secretion in mouse striatum.
作者信息
Leandrou Emmanouela, Chalatsa Ioanna, Vekrellis Kostas, Emmanouilidou Evangelia
机构信息
Department of Chemistry, School of Sciences, National and Kapodistrian University of Athens; Panepistimioupolis Zografou, Athens, 15772, Greece.
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, 11527, Greece.
出版信息
NPJ Parkinsons Dis. 2025 Sep 26;11(1):276. doi: 10.1038/s41531-025-01110-z.
The secretion of α-synuclein from presynaptic terminals is controlled by neuronal activity through a calcium-dependent mechanism. To address the role of voltage gated calcium channels in this process, we used reverse brain microdialysis to monitor α-synuclein release in vivo in the presence of selective channel inhibitors. Our results revealed that the ω-conotoxin GVIA-sensitive N-type calcium channels are the major mediators of stimulated α-synuclein secretion in mouse striatum.
α-突触核蛋白从突触前终末的分泌通过一种钙依赖机制受神经元活动控制。为了探究电压门控钙通道在此过程中的作用，我们使用反向脑微透析技术，在存在选择性通道抑制剂的情况下监测体内α-突触核蛋白的释放。我们的结果表明，ω-芋螺毒素GVIA敏感的N型钙通道是小鼠纹状体中受刺激的α-突触核蛋白分泌的主要介质。
Zotero 插件