Mujde Cem, Bisgin Atil
Department of Biotechnology, Institute of Natural and Applied Sciences, Cukurova University, Adana 01330, Türkiye.
Biomedicines. 2025 Sep 18;13(9):2291. doi: 10.3390/biomedicines13092291.
: Mesenchymal stem cells (MSCs) offer promising prospects for novel treatment modalities in cellular therapies and artificial organ production. Despite a surge in artificial tissue research, there is a dearth of comprehensive studies detailing the entire process from stem cells to tissue production, coupled with a scarcity. This study, however, presents the utility of extra-embryonic MSCs derived from placental tissue, traditionally considered as medical waste. : Within a 3-dimensional cell culture system, histological assessments, and comprehensive optimization studies, the entire process required for artificial tissue production is addressed. : The results obtained are encouraging regarding the advancement of cellular therapies and artificial tissue engineering. However, challenges such as biopolymer degradation highlight the necessity for multistep approaches. Each analysis within this study delves into the discussion and optimization of key steps in artificial tissue production. Consequently, this study not only represents one of the first of its kind but also lays the groundwork for future investigations into relevant clinical applications.
间充质干细胞（MSCs）在细胞治疗和人工器官生产的新型治疗方式中展现出了广阔前景。尽管人工组织研究激增，但缺乏详细描述从干细胞到组织生产全过程的综合研究，且相关研究稀缺。然而，本研究展示了源自胎盘组织的胚外间充质干细胞的效用，胎盘组织传统上被视为医疗废物。在三维细胞培养系统、组织学评估和全面优化研究中，探讨了人工组织生产所需的全过程。所获结果对于细胞治疗和人工组织工程的进展而言令人鼓舞。然而，诸如生物聚合物降解等挑战凸显了采取多步骤方法的必要性。本研究中的每项分析都深入探讨了人工组织生产关键步骤的讨论与优化。因此，本研究不仅是同类研究中的首批研究之一，还为未来相关临床应用的研究奠定了基础。
