Tischendorf Patricia, Künnemann Marc-David, Krähling Tobias, Lange Jan Hendrik, Heindel Walter, Beck Laura
Clinic for Radiology, University of Münster and University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany.
Department of Anesthesiology, University of Münster and University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany.
Biomedicines. 2025 Sep 19;13(9):2302. doi: 10.3390/biomedicines13092302.
: To compare the feasibility and image quality of a post-contrast free-breathing radial stack-of-stars 3D T1w turbo-field echo Dixon sequence (3D T1w VANE mDIXON) with a conventional cartesian breath-hold 3D T1w fast-field echo mDIXON sequence in pediatric oncology patients undergoing chest MRI. : A total of 48 children (34 females; mean age 5.3 ± 3.7 years) underwent contrast-enhanced chest MRI, with 24 examined using the 3D T1w VANE mDIXON sequence and 24 with a conventional breath-hold 3D T1w mDIXON sequence. Image quality was independently assessed by three radiologists using a 5-point scale. Signal-to-noise ratio (SNR) was measured at two anatomical sites, a homogeneous paraspinal muscle region (SNR) and the liver apex (SNR), while avoiding vessels and signal inhomogeneities. The presence of respiratory artifacts, total imaging time, and the need for general anesthesia or sedation were recorded. Interobserver agreement was determined using Fleiss's kappa (ϰ), and mean SNR values were compared between groups using an independent samples -test. : The 3D T1w VANE mDIXON sequence yielded significantly higher SNR and SNR (530 ± 120; 570 ± 110 vs. 370 ± 110; 400 ± 90; < 0.001), improved diagnostic image quality by approximately 25%, and reduced respiratory artifacts by about 23%. Interobserver agreement was almost perfect. Importantly, the need for general anesthesia was significantly reduced using the 3D T1w VANE mDIXON ( < 0.001). : Free-breathing 3D T1w VANE mDIXON chest MRI is a feasible and effective imaging approach for pediatric oncology patients, offering superior image quality and reducing the need for general anesthesia compared to conventional methods.
为比较在接受胸部MRI检查的儿科肿瘤患者中，无对比剂自由呼吸径向堆叠星状3D T1加权涡轮场回波狄克逊序列（3D T1w VANE mDIXON）与传统笛卡尔屏气3D T1加权快速场回波mDIXON序列的可行性和图像质量。总共48名儿童（34名女性；平均年龄5.3±3.7岁）接受了对比增强胸部MRI检查，其中24名使用3D T1w VANE mDIXON序列进行检查，24名使用传统屏气3D T1w mDIXON序列进行检查。由三名放射科医生使用5分制独立评估图像质量。在两个解剖部位测量信噪比（SNR），即均匀的椎旁肌区域（SNR）和肝尖（SNR），同时避开血管和信号不均匀性。记录呼吸伪影的存在、总成像时间以及全身麻醉或镇静的需求。使用Fleiss卡方（ϰ）确定观察者间的一致性，并使用独立样本t检验比较组间的平均SNR值。3D T1w VANE mDIXON序列产生的SNR和SNR显著更高（530±120；570±110 vs. 370±110；400±90；P<0.001），诊断图像质量提高了约25%，呼吸伪影减少了约23%。观察者间的一致性几乎完美。重要的是，使用3D T1w VANE mDIXON显著减少了全身麻醉的需求（P<0.001）。自由呼吸3D T1w VANE mDIXON胸部MRI对于儿科肿瘤患者是一种可行且有效的成像方法，与传统方法相比，具有更高的图像质量并减少了全身麻醉的需求。
