Dumitrescu Florentina, Dragonu Livia, Marcu Eugenia-Andreea, Pădureanu Vlad, Stoian Andreea Cristina, Rădoi-Troacă Cristiana-Luiza, Pădureanu Rodica, Duduveche Anca, Georgescu Ilona-Andreea, Giubelan Lucian
Department of Infectious Disease, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
"Victor Babes" Hospital of Infectious Diseases and Pulmonology from Craiova, 200515 Craiova, Romania.
Biomedicines. 2025 Sep 20;13(9):2305. doi: 10.3390/biomedicines13092305.
Human Immunodeficiency Virus (HIV) is a virus that progressively impairs immune function by depleting CD4 + T-lymphocytes, ultimately leading to acquired immunodeficiency syndrome (AIDS). People living with HIV face a higher risk of developing various bone disorders, such as osteopenia, osteoporosis, and osteonecrosis. The aim of this study was to evaluate the bone mineral density (BMD) status, to determine the prevalence of osteopenia/osteoporosis and to identify the risk factors for low BMD in patients living with HIV undergoing antiretroviral treatment (ART), registered in Craiova Regional Center. A retrospective study was conducted between June 2024 and January 2025, including HIV-infected subjects aged over 18 years. The study group included 106 patients. Dual-energy X-ray absorptiometry (DEXA) showed that 87 patients had low BMD, 51% having osteopenia and 31.1% having osteoporosis. We found a statistically significant correlation between low BMD and older age, higher levels HIV viremia, CD4 nadir < 200 cells/mm, prolonged ART exposure and tenofovir disoproxil fumarate containing regimens. These findings support the inclusion of routine bone health monitoring in the standard care of patients with HIV, as well as the need for reevaluation.
人类免疫缺陷病毒（HIV）是一种通过消耗CD4 + T淋巴细胞逐渐损害免疫功能的病毒，最终导致获得性免疫缺陷综合征（AIDS）。感染HIV的人患各种骨骼疾病的风险更高，如骨质减少、骨质疏松和骨坏死。本研究的目的是评估在克拉约瓦地区中心登记的接受抗逆转录病毒治疗（ART）的HIV感染者的骨密度（BMD）状况，确定骨质减少/骨质疏松的患病率，并识别低骨密度的危险因素。2024年6月至2025年1月进行了一项回顾性研究，纳入年龄超过18岁的HIV感染受试者。研究组包括106名患者。双能X线吸收法（DEXA）显示，87名患者骨密度低，其中51%患有骨质减少，31.1%患有骨质疏松。我们发现低骨密度与年龄较大、HIV病毒血症水平较高、CD4最低点<200个细胞/mm³、ART暴露时间延长以及含富马酸替诺福韦二吡呋酯的治疗方案之间存在统计学上的显著相关性。这些发现支持将常规骨骼健康监测纳入HIV患者的标准护理中，以及重新评估的必要性。
