Martinez Tania E, De la Torre-Luque Alejandro, Pedrola-Pons Anna, Suarez-Soto Elizabeth
Department of Psychology, European University of Valencia, 46040 Valencia, Spain.
Department of Legal Medicine, Psychiatry and Pathology, Faculty of Medicine, Office #16, 4th Floor, 3rd Pavilion, Universidad Complutense de Madrid, 2 Seneca Avenue, 28040 Madrid, Spain.
Brain Sci. 2025 Aug 28;15(9):940. doi: 10.3390/brainsci15090940.
: Problematic polydrug use represents a relevant public health concern, with strong relationships with mental health problems and suicide behavior. Existing studies have just focused on problematic use, overlooking the potentially cumulative effect of coexisting substance use and addictive behaviors. This study aims to analyze the association between the polydrug use profile (no problematic use, problematic use of a single drug, and polydrug use) and mental health outcomes, specifically anxiety symptoms, depressive symptoms, and suicide behavior. : A sample of 1307 Spanish young adults (66.2% male; = 21.2 years, = 3.31) were assessed for problematic use of substances and behavioral addictions as well as for the internalizing symptoms and suicide behavior. Participants were categorized into three groups: no problematic drug use ( = 880), problematic single drug use ( = 316), and polydrug use ( = 111). : Results showed an increasing level in depressive symptoms and suicide behavior with polydrug use, with significant differences between groups ( < 0.05). Moreover, both groups of problematic use presented higher levels of anxiety than no-use participants, regardless of the number of use modalities. : These findings suggest that problematic polydrug use is associated with greater clinical severity, particularly in terms of depressive symptoms and suicide behavior, while anxiety remains elevated even when a problematic single drug pattern is observed. This study highlights the importance of considering polydrug use in dual diagnosis and the need for an integrative clinical approach.
问题性多药滥用是一个相关的公共卫生问题，与心理健康问题和自杀行为密切相关。现有研究仅关注问题性使用，而忽略了共存物质使用和成瘾行为的潜在累积效应。本研究旨在分析多药使用情况（无问题性使用、单一药物问题性使用和多药使用）与心理健康结果之间的关联，特别是焦虑症状、抑郁症状和自杀行为。：对1307名西班牙年轻人（66.2%为男性；平均年龄=21.2岁，标准差=3.31）进行了物质使用和行为成瘾问题性使用以及内化症状和自杀行为的评估。参与者被分为三组：无问题性药物使用组（n = 880）、单一药物问题性使用组（n = 316）和多药使用组（n = 111）。：结果显示，多药使用时抑郁症状和自杀行为水平升高，组间存在显著差异（p < 0.05）。此外，无论使用方式的数量如何，两组问题性使用组的焦虑水平均高于未使用组参与者。：这些发现表明，问题性多药滥用与更高的临床严重程度相关，特别是在抑郁症状和自杀行为方面，而即使观察到单一药物问题性模式，焦虑水平仍然升高。本研究强调了在双重诊断中考虑多药使用的重要性以及综合临床方法的必要性。
