Han Lingyu, Dong Nuo, Yang Jixin, Hu Bing
Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian 116600, China.
Faculty of Social and Life Sciences, Wrexham University, Plas Coch, Mold Road, Wrexham LL11 2AW, UK.
Biomolecules. 2025 Sep 12;15(9):1311. doi: 10.3390/biom15091311.
Zinc is an essential mineral for the body, with chelated zinc valued for its superior absorption efficiency and bioavailability. This review systematically examines peptide-zinc interactions, covering fundamental concepts, historical evolution, current insights, clinical relevance, technological innovations, and future outlooks. It delves into chelation mechanisms and structural theories, summarizes historical milestones in bioavailability research-particularly aquatic protein-zinc interactions-and details current studies on chelation efficacy and interaction dynamics. Clinical applications in nutritional supplements, therapeutic potential, and trial progress are discussed, alongside advances in analytical techniques, complex synthesis, and computational modeling. Future directions highlight emerging trends, application prospects, and challenges in bioavailability research, offering a comprehensive framework for subsequent investigations and practical implementations.
锌是人体必需的矿物质，螯合锌因其卓越的吸收效率和生物利用度而备受重视。本综述系统地研究了肽与锌的相互作用，涵盖基本概念、历史演变、当前见解、临床相关性、技术创新和未来展望。它深入探讨了螯合机制和结构理论，总结了生物利用度研究的历史里程碑——特别是水生蛋白质与锌的相互作用——并详细介绍了当前关于螯合效果和相互作用动力学的研究。讨论了营养补充剂中的临床应用、治疗潜力和试验进展，以及分析技术、复合物合成和计算建模方面的进展。未来方向突出了生物利用度研究中的新兴趋势、应用前景和挑战，为后续研究和实际应用提供了一个全面的框架。
