Koufopoulos Nektarios I, Pouliakis Abraham, Samaras Menelaos G, Skarentzos Kostantinos, Nastos Theofanis, Boutas Ioannis, Kontogeorgi Adamantia, Zanelli Magda, Palicelli Andrea, Zizzo Maurizio, Broggi Giuseppe, Caltabiano Rosario, Salzano Serena, Goutas Dimitrios, Pateras Ioannis S, Syrios John, Psyrri Amanda, Arkadopoulos Nikolaos, Panayiotides Ioannis G
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece.
Breast Unit, Rea Maternity Hospital, P. Faliro, 17564 Athens, Greece.
Diagnostics (Basel). 2025 Sep 17;15(18):2356. doi: 10.3390/diagnostics15182356.
Invasive lobular carcinoma (ILC) is the most common special type of breast carcinoma, accounting for 5-15% of all breast carcinoma cases. Its metastatic pattern differs from that of invasive breast carcinoma of no special type, with ILC metastases to the peritoneum, gastrointestinal tract, and female genital tract being more frequent. This literature review focuses on ILC cases with metastasis to the female genital tract (FGT). Searches were conducted in medical databases including PubMed, Scopus, and Web of Science, using specific keywords. Inclusion criteria centered on studies presenting one or more cases of patients with ILC metastasis to the FGT and English language publications. Exclusion criteria included articles that did not present original research findings, studies with insufficient data, and publications in languages other than English. A thorough analysis of 154 results from PubMed, 56 from Scopus, and 173 from Web of Science after the application of inclusion and exclusion criteria resulted in the inclusion of 54 manuscripts describing 61 cases. The demographic, clinicopathological, and therapeutic aspects of ILC metastases to the FGT were reviewed and the differential diagnosis and prognosis for each anatomic location in the FGT were discussed separately. Our analysis of the data showed that the restricted mean survival time was 186 ± 30.7 months and that a negative ER on a secondary tumor was found to be linked to worse patient survival rates. Also of note is the fact that in 37.7% of cases there was involvement of multiple FGT anatomic locations and in 36% of cases there were metastases in organs or anatomic locations other than the FGT. To our knowledge, our study is the only one to describe the features of patients with secondary FGT involvement from ILC.
浸润性小叶癌（ILC）是最常见的特殊类型乳腺癌，占所有乳腺癌病例的5%-15%。其转移模式不同于非特殊类型的浸润性乳腺癌，ILC转移至腹膜、胃肠道和女性生殖道更为常见。这篇文献综述聚焦于转移至女性生殖道（FGT）的ILC病例。使用特定关键词在包括PubMed、Scopus和Web of Science在内的医学数据库中进行检索。纳入标准集中于呈现1例或更多例ILC转移至FGT患者的研究以及英文出版物。排除标准包括未呈现原始研究结果的文章、数据不足的研究以及非英文语言的出版物。在应用纳入和排除标准后，对来自PubMed的154条结果、来自Scopus的56条结果和来自Web of Science的173条结果进行全面分析，最终纳入了54篇描述61例病例的手稿。对ILC转移至FGT的人口统计学、临床病理和治疗方面进行了综述，并分别讨论了FGT各解剖部位的鉴别诊断和预后。我们对数据的分析表明，受限平均生存时间为186±30.7个月，并且发现继发性肿瘤雌激素受体阴性与患者较差的生存率相关。同样值得注意的是，在37.7%的病例中存在多个FGT解剖部位受累，在36%的病例中存在FGT以外器官或解剖部位的转移。据我们所知，我们的研究是唯一描述ILC继发性FGT受累患者特征的研究。
