Cocuz Iuliu-Gabriel, Manole Martin, Popelea Maria-Cătălina, Niculescu Raluca, Cocuz Maria Elena, Sabău Adrian Horațiu, Tinca Andreea Cătălina, Cozac-Szőke Andreea Raluca, Chiorean Diana Maria, Ioniță Alexandru Constantin, Budin Eugenia Corina, Radu Georgian-Nicolae, Szasz Emoke Andrea, Cotoi Ovidiu Simion
Pathophysiology Department, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.
Clinical Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
Diagnostics (Basel). 2025 Sep 18;15(18):2377. doi: 10.3390/diagnostics15182377.
: Basal cell carcinoma (BCC) of the skin is a type of non-melanocytic skin cancer. The European incidence of non-melanocytic skin cancers is 14.2 per 100,000 people, with a mortality rate of 0.5, thus ranking Europe third in the world in terms of incidence and mortality rate, according to the WHO Global Cancer Observatory. The objective of this study was to highlight the histological, epidemiological, and clinicopathological aspects of BCCs diagnosed in the Clinical Pathology Department of the Mures Clinical County Hospital between January 2021 and December 2024. : We performed a retrospective, descriptive, observational study between January 2021 and December 2024 in the Mureș Clinical County Hospital, Targu Mureș, Romania, by analysing data from histopathological reports and histological slides from patients with a positive diagnosis of BCC. The inclusion criteria for this study consisted of patients who presented a histopathological diagnosis of BCCs during the study period. Lesions were divided into two study cohorts-a general cohort and head and neck cohort. The collected data included epidemiological data, macroscopic features, and microscopical characteristics. : A total of 540 lesions were included in this study (general cohort), of which 395 were included in the head and neck cohort. This study revealed a higher incidence of BCC in 2024, affecting mostly urban patients ( < 0.001), with more aggressive forms ( < 0.001). The tumours found among males ( = 0.0189) and in rural patients ( = 0.0126) were bigger, but the tumoural volumes decreased over time ( < 0.001). The mixed form of BCC was associated with more aggressive histological subtypes ( < 0.001). : BCC presents variability depending on age, gender, environment of origin, and topography, as well as histological subtype and aggressiveness, thus highlighting the need for a personalised approach in terms of diagnostics and treatment.
皮肤基底细胞癌（BCC）是一种非黑素细胞性皮肤癌。根据世界卫生组织全球癌症观测站的数据，欧洲非黑素细胞性皮肤癌的发病率为每10万人中有14.2例，死亡率为0.5，因此在发病率和死亡率方面，欧洲在世界上排名第三。本研究的目的是突出2021年1月至2024年12月期间在穆列什临床县医院临床病理科诊断的基底细胞癌的组织学、流行病学和临床病理特征。
我们于2021年1月至2024年12月在罗马尼亚特尔古穆列什的穆列什临床县医院进行了一项回顾性、描述性、观察性研究，通过分析基底细胞癌阳性诊断患者的组织病理学报告和组织学切片数据。本研究的纳入标准包括在研究期间呈现基底细胞癌组织病理学诊断的患者。病变分为两个研究队列——一个总体队列和头颈部队列。收集的数据包括流行病学数据、宏观特征和微观特征。
本研究共纳入540个病变（总体队列），其中395个纳入头颈部队列。本研究显示，2024年基底细胞癌发病率较高，主要影响城市患者（<0.001），且形式更具侵袭性（<0.001）。在男性患者（=0.0189）和农村患者中发现的肿瘤（=0.0126）更大，但肿瘤体积随时间减小（<0.001）。基底细胞癌的混合形式与更具侵袭性的组织学亚型相关（<0.001）。
基底细胞癌因年龄、性别、起源环境、部位以及组织学亚型和侵袭性而呈现出变异性，因此突出了在诊断和治疗方面采用个性化方法的必要性。
