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前列腺切除术后尿失禁的术前磁共振成像预测指标

Preoperative MRI Predictors for Post-Prostatectomy Urinary Incontinence.

作者信息

Simonato Franco Alchiede, Mantica Guglielmo, Beverini Martina, Ambrosini Francesca, Chierigo Francesco, Giasotto Veronica, Pavan Nicola, Simonato Alchiede, Terrone Carlo

机构信息

Urology Clinic, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127 Palermo, Italy.

Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genoa, 16126 Genova, Italy.

出版信息

Cancers (Basel). 2025 Sep 15;17(18):3004. doi: 10.3390/cancers17183004.

Abstract

: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. : Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo radiotherapy, hormone therapy, or transurethral resection of the prostate, and who had a follow-up longer than 12 months were selected. For each patient, a radiology physician evaluated the preoperative magnetic resonance imaging, measuring prostatic and membranous urethral length, classifying prostatic apex according to the Lee Type, and estimating the presence of the median lobe and its intravesical protrusion. Multivariate logistic regression models evaluated the influence of anatomic features measured in magnetic resonance imaging on urinary continence recovery, defined as daily pad usage less than or equal to one, considering age, body mass index, prostate volume, International Prostatic Symptoms Score, the usage of a nerve sparing technique, and the International Society of Urological Pathology classification. : A total of 95 patients who underwent robot-assisted radical prostatectomy were enrolled. Median age, median body mass index, and median PSA density were respectively 66 years (62, 70), 26.12 kg/m (23.88, 28.09), and 0.16 ng/mL/cc (0.10, 0.26). Patients with urinary continence ranged from 32 (33.7%) at baseline to 93 (97.8%) after one year from surgery. At preoperative magnetic resonance, Lee Type was almost equally distributed, but Type C was less represented (18 patients, 18.9%) and Type D was more frequent (31 patients, 32.2%). Median prostatic urethral length, median membranous urethral length, and median intravesical prostatic protrusion were respectively 36 mm (31, 42), 15 mm (13, 16), and 0 mm (0, 0). Multivariate logistic regression models showed no statistical significance, except for Lee Type C and A comparison at vesical catheter removal after surgery (OR 0.17; 95% CI 0.04-0.71; -value 0.01). : The results of this study showed that patients who had Lee Type C might have higher probability of early urinary continence recovery, but no further statistically significant correlations were found.

摘要

我们研究了前列腺形态在前列腺切除术后尿失禁的术前多参数磁共振成像中的预测作用。选取2018年2月至2021年10月期间接受机器人辅助根治性前列腺切除术、术前无尿失禁、未接受放疗、激素治疗或经尿道前列腺切除术且随访时间超过12个月的患者。对于每位患者,放射科医生评估术前磁共振成像,测量前列腺和膜部尿道长度,根据Lee分型对前列腺尖进行分类,并评估中叶的存在及其膀胱内突出情况。多因素逻辑回归模型评估磁共振成像中测量的解剖学特征对尿失禁恢复的影响,尿失禁恢复定义为每日使用尿垫少于或等于1片,同时考虑年龄、体重指数、前列腺体积、国际前列腺症状评分、保留神经技术的使用情况以及国际泌尿病理学会分类。共纳入95例接受机器人辅助根治性前列腺切除术的患者。中位年龄、中位体重指数和中位前列腺特异性抗原密度分别为66岁(62, 70)、26.12 kg/m²(23.88, 28.09)和0.16 ng/mL/cc(0.10, 0.26)。尿失禁患者从基线时的32例(33.7%)降至术后1年时的93例(97.8%)。在术前磁共振成像中,Lee分型分布基本均匀,但C型较少(18例,18.9%),D型较多(31例,32.2%)。前列腺尿道中位长度、膜部尿道中位长度和膀胱内前列腺突出中位长度分别为36 mm(31, 42)、15 mm(13, 16)和0 mm(0, 0)。多因素逻辑回归模型显示无统计学意义,除了C型Lee与术后拔除膀胱导管时的A比较(比值比0.17;95%置信区间0.04 - 0.71;P值0.01)。本研究结果表明,Lee分型为C型的患者可能有更高的早期尿失禁恢复概率,但未发现进一步的统计学显著相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5e/12468880/0dcba86070e6/cancers-17-03004-g001.jpg

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