揭示血管紧张素 II 受体阻滞剂的新型治疗潜力

Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

作者信息

Chatzipieris Filippos Panteleimon, Mavromoustakou Kiriaki, Matsoukas John M, Mavromoustakos Thomas

机构信息

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.

First Cardiology Department, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.

出版信息

Int J Mol Sci. 2025 Sep 10;26(18):8819. doi: 10.3390/ijms26188819.

DOI:10.3390/ijms26188819

PMID:41009387

Abstract

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in this context is the renin-angiotensin-aldosterone system (RAAS), a crucial regulator of blood pressure and fluid homeostasis, and a central focus in the treatment of chronic cardiovascular conditions such as arterial hypertension (AH) and heart failure (HF). Interestingly, novel investigations show that AT1 antagonists (sartans) are able to broaden their therapeutic scope and potentially combat other diseases such as neurodegenerative diseases, cancer, and osteoarthritis, and even help people with methamphetamine and opioid addiction.

摘要

制药公司不断研发新型药物和治疗方法，以改善每一位患者的生活，通常遵循一种模式：针对特定病症使用特定药物。有证据表明，不同药物对不同病理状况可能产生积极影响。通过药物重新利用（也称为药物重新定位、重新定性或重新任务分配）可以揭示现有疗法的全部潜力，这涉及确定已批准或正在研究的药物在其原始适应症之外的新治疗用途。在这方面的一个重要靶点是肾素-血管紧张素-醛固酮系统（RAAS），它是血压和体液平衡的关键调节因子，也是治疗慢性心血管疾病如动脉高血压（AH）和心力衰竭（HF）的核心关注点。有趣的是，新的研究表明，AT1拮抗剂（沙坦类药物）能够扩大其治疗范围，并有可能对抗其他疾病，如神经退行性疾病、癌症和骨关节炎，甚至帮助患有甲基苯丙胺和阿片类药物成瘾的人。