WW Domain-Containing E3 Ubiquitin Protein Ligase 1 (WWP1) as a Factor in Obesity-Related Metabolic Disorders: Emerging Molecular Mechanisms in Metabolic Tissues.

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a member of the homologous to E6AP C-terminus-type E3 ubiquitin protein ligase family. Although WWP1 plays a role in several human diseases, including infectious diseases, neurological disorders, and cancers, there is emerging evidence that WWP1 is also associated with metabolic disorders. In this review, we discuss the regulation and molecular function of WWP1 and its contribution to obesity-related metabolic disorders, particularly in white adipose tissue and the liver. We highlight the need for further research to deepen our understanding of how WWP1 may be implicated in metabolic dysfunction and facilitate the development of novel therapeutic strategies that target WWP1.