Szarwaryn Aleksandra, Bartkowiak Wojciech, Olszewski Tomasz K, Bazylińska Urszula
Department of Physical and Quantum Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Int J Mol Sci. 2025 Sep 22;26(18):9259. doi: 10.3390/ijms26189259.
The extensive use of submicron emulsion systems, particularly those stabilized by nonionic surfactants, with their proven effectiveness and safety profile, provides a reassuring foundation for our research. Consequently, we designed and engineered new submicron emulsion formulations stabilized with a biocompatible surfactant polyoxyethylated cocoamine, whose nonionic character is due to a high degree of polyoxyethylation. We chose oleic acid as the oil phase, a fatty acid known for its beneficial properties. This led to novel biocompatible nanoemulsions with high stability and cosurfactant-free microemulsions. The dynamic light scattering studies confirmed that both formulations have a nanometric size and low polydispersity index values. Moreover, transmission electron microscopy verified the nanodroplets' morphological homogeneity and spherical shape. The resulting nanoplatforms can be applied to carry bioactive agents in the pharmaceutical and cosmetic fields. For this reason, we solubilized newly synthesized 5-dimethylamino-5'-nitro-2,2'-bithiophene as a model hydrophobic cargo for delivering poorly water-soluble compounds. This dye was chosen due to its strong solvatochromic behavior and suitability for micropolarity analysis via UV-Vis spectroscopy. We also present a simple method for rapid micropolarity screening to assess the type of nanodispersion via solvatochromic shift as an alternative procedure for evaluating of the oils used to fabricate nanoformulations for pharmaceutical and cosmetic purposes.
亚微米乳液体系的广泛应用，特别是那些由非离子表面活性剂稳定的体系，凭借其已被证实的有效性和安全性，为我们的研究提供了可靠的基础。因此，我们设计并构建了以生物相容性表面活性剂聚氧乙烯化椰油胺稳定的新型亚微米乳液配方，其非离子特性归因于高度的聚氧乙烯化。我们选择油酸作为油相，这是一种因其有益特性而闻名的脂肪酸。这产生了具有高稳定性的新型生物相容性纳米乳液和无助表面活性剂的微乳液。动态光散射研究证实，这两种配方都具有纳米尺寸和低多分散指数值。此外，透射电子显微镜验证了纳米液滴的形态均匀性和球形形状。所得的纳米平台可应用于在制药和化妆品领域携带生物活性剂。因此，我们将新合成的5-二甲基氨基-5'-硝基-2,2'-联噻吩作为一种模型疏水性货物进行增溶，用于递送水溶性差的化合物。选择这种染料是因为其强烈的溶剂化显色行为以及适用于通过紫外-可见光谱进行微极性分析。我们还提出了一种简单的快速微极性筛选方法，通过溶剂化显色位移来评估纳米分散体的类型，作为评估用于制造制药和化妆品用途纳米制剂的油类的替代方法。
