Smolarczyk Joanna, Piłat Patrycja, Blanch Jordi, Cetnarowska Aleksandra, Dębski Paweł, Torrent Aurora, Batalla Iolanda, Piegza Magdalena
Department of Psychoprophylaxis, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Life (Basel). 2025 Aug 28;15(9):1368. doi: 10.3390/life15091368.
Electroconvulsive therapy (ECT) is a non-pharmacological biological treatment method used to treat major depression, bipolar disorder, schizophrenia, catatonia, and some other psychiatric conditions. Despite its high effectiveness, it is often used when other methods, such as pharmacotherapy and psychotherapy, fail to improve treatment outcomes. The refinement of this particular therapy may increase the popularity of this method, and among the currently studied therapy modifiers is protocolised hyperventilation. Hyperventilation is implemented to improve ventilation and gas exchange, reduce shortness of breath, improve blood oxygenation, and prevent hypoxia. Research suggests that hyperventilation during ECT may prolong the duration of epileptic seizures, potentially enhancing the effectiveness of the therapy. However, research on hyperventilation during ECT still poses many questions regarding its benefits and side effects. Innovative studies on ECT with concomitant hyperventilation focus on monitoring parameters such as CO, EEG, and cardiovascular responses. Current research directions worth exploring also include the utilisation of modern ECT devices or determining the neurotrophin concentration to better understand the mechanism of action at the neurochemical level. The personalization of therapy, including adjustment of ECT parameters to patients' specific symptoms, can reduce the risk of failure and increase effectiveness.
电休克疗法（ECT）是一种用于治疗重度抑郁症、双相情感障碍、精神分裂症、紧张症及其他一些精神疾病的非药物生物治疗方法。尽管其疗效显著，但通常在药物治疗和心理治疗等其他方法无法改善治疗效果时才会使用。这种特殊疗法的改进可能会提高其受欢迎程度，目前正在研究的治疗调节方法之一是规范化过度通气。实施过度通气是为了改善通气和气体交换、减轻呼吸急促、改善血液氧合并预防缺氧。研究表明，ECT期间的过度通气可能会延长癫痫发作的持续时间，从而有可能提高治疗效果。然而，关于ECT期间过度通气的益处和副作用，仍存在许多问题。关于ECT联合过度通气的创新性研究集中在监测诸如一氧化碳（CO）、脑电图（EEG）和心血管反应等参数上。当前值得探索的研究方向还包括利用现代ECT设备或测定神经营养因子浓度，以便更好地理解神经化学水平上的作用机制。治疗的个性化，包括根据患者的具体症状调整ECT参数，可以降低治疗失败的风险并提高疗效。
