Bozkürk Mine Büşra, Özdel Kadir, Çiçek Bilge Ozan, Önder Özkan, Yıldız Selin, Öztürk Alpaslan
Ankara Etlik City Hospital, Department of Clinical Biochemistry, 06170 Ankara, Türkiye.
Ankara Etlik City Hospital, Department of Psychiatry, 06170 Ankara, Türkiye.
Life (Basel). 2025 Sep 17;15(9):1456. doi: 10.3390/life15091456.
Annexin A3 (ANXA3) is a calcium-binding protein that plays a role in membrane phospholipid metabolism and inflammation, and significant alterations have been shown in some psychotic disorders. Because its association with major depressive disorder (MDD) is unclear, we aimed to compare serum ANXA3 levels in patients with MDD and healthy controls and to investigate their relationship with depression severity. Serum ANXA3 concentrations in 90 patients diagnosed with MDD and 90 healthy controls were measured by ELISA. Depression severity was assessed using the Beck Depression Inventory (BDI). Serum ANXA3 levels were significantly lower in patients with MDD compared to controls ( < 0.001). ANXA3 showed negative correlations with neutrophil count, platelet count, neutrophil-to-lymphocyte ratio (NLR), glucose, creatinine, and ALT levels, and positive correlations with lymphocyte and red blood cell counts. We found that low ANXA3 levels, high NLR, and glucose dysregulation predicted greater depression severity. Using ROC analysis, we demonstrated that ANXA3 has high discriminatory power in distinguishing moderate to severe cases of MDD (AUC > 0.90). ANXA3 may serve as a biomarker of depression severity. Further studies are needed to clarify its clinical utility and confirm whether ANXA3 alterations represent state or trait markers of depression.
膜联蛋白A3（ANXA3）是一种钙结合蛋白，在膜磷脂代谢和炎症中发挥作用，并且在一些精神障碍中已显示出显著改变。由于其与重度抑郁症（MDD）的关联尚不清楚，我们旨在比较MDD患者和健康对照者的血清ANXA3水平，并研究它们与抑郁严重程度的关系。采用酶联免疫吸附测定法（ELISA）测量了90例诊断为MDD的患者和90例健康对照者的血清ANXA3浓度。使用贝克抑郁量表（BDI）评估抑郁严重程度。与对照组相比，MDD患者的血清ANXA3水平显著降低（<0.001）。ANXA3与中性粒细胞计数、血小板计数（PLT）、中性粒细胞与淋巴细胞比值（NLR）、血糖、肌酐和丙氨酸转氨酶（ALT）水平呈负相关，与淋巴细胞和红细胞计数呈正相关。我们发现低ANXA3水平、高NLR和血糖失调预示着更严重的抑郁。通过ROC分析，我们证明ANXA3在区分中度至重度MDD病例方面具有较高的鉴别能力（曲线下面积>0.90）。ANXA3可能作为抑郁严重程度的生物标志物。需要进一步研究以阐明其临床实用性，并确认ANXA3的改变是代表抑郁的状态还是特质标志物。
